Fostering a High-Functioning Team in Cancer Care Using the 4R Oncology Model: Assessment in a Large Health System and a Blueprint for Other Institutions.

Purpose: Delivering cancer care by high-functioning multidisciplinary teams promises to address care fragmentation, which threatens care quality, affects patient outcomes, and strains the oncology workforce. We assessed whether the 4R Oncology model for team-based interdependent care delivery and patient self-management affected team functioning in a large community-based health system.

Methods: 4R was deployed at four locations in breast and lung cancers and assessed along four characteristics of high-functioning teams: recognition as a team internally and externally; commitment to an explicit shared goal; enablement of interdependent work to achieve the goal; and engagement in regular reflection to adapt objectives and processes.

Amino acid substitution at position 44 of matrix protein 2 of an avirulent H5 avian influenza virus is crucial for acquiring the highly pathogenic phenotype in chickens.

The pathogenicity of highly pathogenic avian influenza (HPAI) viruses is dependent on multiple factors, but the sequence at the HA cleavage site plays the most important role. To better understand the mechanism of virulence of HPAI virus, an avirulent H5 avian influenza virus, A/teal/Tottori/150/02 (H5N3, teal/150), was passaged in respiratory organs of chickens to generate a virus with a highly pathogenic phenotype. After 12 consecutive passages, the virus (strain 12a) became highly pathogenic, with a 100 % mortality rate in chickens.

Complete Fermi surface in BaFe2As2 observed via Shubnikov-de Haas oscillation measurements on detwinned single crystals.

We show that the Fermi surface (FS) in the antiferromagnetic phase of BaFe(2)As(2) is composed of one hole and two electron pockets, all of which are three dimensional and closed, in sharp contrast to the FS observed by angle-resolved photoemission spectroscopy. Considerations on the carrier compensation and Sommerfeld coefficient rule out existence of unobserved FS pockets of significant sizes. A standard band structure calculation reasonably accounts for the observed FS, despite the overestimated ordered moment.

FTIR evidence that the PsbP extrinsic protein induces protein conformational changes around the oxygen-evolving Mn cluster in photosystem II.

Extrinsic proteins of photosystem II (PSII) regulate the oxygen-evolving reaction performed at the Mn cluster by controlling the binding properties of the indispensable cofactors Ca(2+) and Cl(-). However, the molecular mechanism underlying this regulation is not yet understood. We have investigated the structural couplings of the extrinsic proteins PsbO, PsbP, and PsbQ of higher plants with the Mn cluster using Fourier transform infrared (FTIR) spectroscopy.