Prognostic value of left atrial reverse remodelling in patients hospitalized with acute decompensated heart failure.

Aims: Left atrial (LA) volume index (LAVI) in chronic heart failure (HF) predicts cardiovascular outcomes. However, the association between LAVI reduction during acute decompensated HF (ADHF) and its prognostic potential is limited. We hypothesized that LA reverse remodelling (LARR) after ADHF therapy would be associated with better clinical outcomes.

Attenuation of hepatitis A antibody after immunization with hepatitis A vaccine (Aimmugen) in people living with HIV.

Aim: Hepatitis A (HA) is a vaccine-preventable disease. In regions with good sanitation, men who have sex with men (MSM) are the key affected populations. During the 2018-2019 HA outbreak among MSM in Japan, we actively vaccinated MSM living with HIV (MSM-LWHIV) with Aimmugen.

Predictors associated with a better response to the Japanese aluminum-free hepatitis A vaccine, Aimmugen , for people living with HIV.

Aim: After the hepatitis A virus (HAV) outbreak among men who have sex with men (MSM) around 2018, the importance of HAV vaccination was emphasized, especially for MSM-living with human immunodeficiency virus (MSM-LWHIV). Aimmugen is licensed and distributed exclusively in Japan. While administration of three doses is recommended, 85% of recipients in the general population were reported to acquire seroprotection after the second dose.

Changes in survival and causes of death among people living with HIV: Three decades of surveys from Tokyo, one of the Asian metropolitan cities.

Introduction: Survival among people living with HIV (PLWH) has dramatically improved in the antiretroviral therapy (ART) era. This is the first study in Asia to describe three decades of surveys on survival and causes of death among PLWH.

Methods: We included 1121 HIV-infected patients, categorized into three period groups according to date of first visit: 1986-1996 (Pre-ART); 1997-2007 (Early-ART); and 2008-2018 (Late-ART).

Lactobacillus reuteri DSM 17938 and Magnesium Oxide in Children with Functional Chronic Constipation: A Double-Blind and Randomized Clinical Trial.

Objective: Chronic functional constipation is a frequent condition. The aim of the study was to evaluate the efficacy of the probiotic Lactobacillus (L.) reuteri DSM 17938 and magnesium oxide (MgO) for relieving chronic functional constipation in children.

Association Between Cerebral Small Vessel Disease and Central Motor Conduction Time in Patients with Vascular Risk.

Background And Purpose: Cerebral small vessel disease (CSVD) is related to motor function disturbance. It includes several types: lacunar infarction, white matter hyperintensity, cerebral microbleeds (CMBs), and enlarged perivascular spaces (EPVS). Transcranial magnetic stimulation (TMS) has been successfully used to evaluate the function of the pyramidal tract.

[Milk, Daily products and Bone health.Effect of milks and daily products on bone health.].

In Japan, nutrition education programs to prevent osteoporosis and osteoporotic fractures have focused primarily on increasing dietary calcium intake and recommended the consumption of milk and dairy products. However, the effect of milk and dairy product consumption on bone density loss or fracture incidence in Japanese has rarely been evaluated in randomized controlled studies. In the present study, we reviewed the literature investigating the consumption of milk and dairy products in relation to bone density and fracture risk.

[Nutrition and bone health. Soybean and soy foods, and bone health].

Soybean and various types of soy products, such as natto, tofu, miso, and soy sauce, have long been consumed in Japan. Soybean, a rich source of plant proteins, contains a relatively high amount of calcium as well as being an important source of isoflavones, a group of substances whose chemical structure is similar to that of estrogen. Natto, fermented soybeans, contains vitamin K, which is involved in the activation of osteocalcin.

[Calcium in aging, health, and anti-aging. Significance of calcium supplement for anti-aging].

For prevention of osteoporosis and debilitating bone fractures, poor calcium intake has long been a major public health problem in Japan. However, few randomized controlled studies have been conducted to clarify the relationship between calcium intake and bone mineral density, and the effect of the prevention of bone fractures. Therefore we reviewed the articles about the evidence for calcium intake and bone fracture incidence in European, American and Asian.

[Allowance of optimal calcium intake for the prevention of osteoporosis and osteoporotic fractures].

One of the main focuses of lifestyle modification for the prevention of osteoporosis and osteoporotic fractures in Japan is improvement in dietary calcium intake. However, virtually no randomized controlled trial to assess the preventive effects of administration of calcium on the risk of fractures has been conducted in Japan. In this study, we reviewed all the scientific papers currently available from medical literature databases to propose evidence-based recommendations on the preventive procedures for osteoporosis.

A mutation in the flavin-containing monooxygenase 3 gene and its effects on catalytic activity for N-oxidation of trimethylamine in vitro.

To clarify the mutation of the flavin-containing monooxygenase (FMO) 3 gene causing fish-odor syndrome, we analyzed the FMO3 gene of a Thai subject who possibly suffered from fish-odor syndrome. A novel mutation, a single-base substitution from G to A at the position of 265 (G265A), was identified in exon 3. The mutation caused an amino acid substitution from valine to isoleucine at residue 58 (V58I).

[Optimization of calcium intake for the prevention of osteoporosis and osteoporotic fractures: a review of the evidence].

One of the main focuses of lifestyle modification for the prevention of osteoporosis and osteoporotic fractures in Japan is improvement in dietary calcium intake. However, virtually no randomized controlled trial to assess the preventive effects of administration of calcium on the risk of fractures has been conducted in Japan. In this study, we reviewed all the scientific papers currently available from medical literature databases to propose evidence-based recommendations on the preventive procedures for osteoporosis.