ENDO-ACAB EARLY POSTOPERATIVE PERIOD RESULTS: ANALYSIS AND COMPARISON.

Endoscopic atraumic coronary artery bypass grafting (EndoACAB) is a novel approach in the treatment of ischemic heart disease compared to traditional coronary artery bypass grafting (CABG). Analyzing the early and late outcome of EndoACAB is very important. EndoACAB was performed in "Tbilisi Heart and Vascular Clinic" for the first time in Georgia in 2015.

Some Aspects of Role of Nitric Oxide in the Mechanisms of Hypertension (Experimental Study).

Background: Modulation of endothelial function is a therapeutic option to reduce some of the significant complications of hypertension. However, the relationship between endothelial dysfunction reduced nitric oxide (NO) production, and the development of hypertension is not fully understood. To establish a potential pathogenetic link between impaired NO synthesis and hypertension, we investigated the results of competitive interaction of the substrate of NO synthase, L-arginine, and its analog, an non-selective inhibitor of NO synthase, N-nitro-methyl ether-L-arginine (L-NAME), in experimental rats.

COMPARISON OF EARLY POST-OPERATIVE PERIOD OF ENDO-ACAB WITH OFF-PUMP CABG: RETROSPECTIVE STUDY CONDUCTED AT TBILISI HEART AND VASCULAR CLINIC.

Our aim was to compare early post-operative period of Endo-ACAB with OPCABG. We retrospectively studied 760 cases of all patients who had underwent urgent or planned coronary artery bypass grafting at the "Tbilisi Heart and Vascular Clinic" from November 2015 till November 2017. Patients were divided into two group: first group patients who had underwent Endo-ACAB and second group patients who had underwent OPCABG.

COMBINATION THERAPY EFFECTIVENESS OF EZETIMIBE AND ATORVASTATIN IN PATIENTS WITH ACUTE CORONARY SYNDROME.

Atorvastatin reduces low-density lipoprotein (LDL) cholesterol levels and the risk of cardiovascular events, but whether the addition of ezetimibe (EZE) , a nonstatin drug that reduces intestinal cholesterol absorption, can reduce the rate of cardiovascular events further is not known. We conducted a 16-week one-center, prospective, randomized, and open-label clinical trial, involving 323 patients who had been hospitalized for an acute coronary syndrome within the preceding 14 days. They were received atorvastatin 20 mg during 28 days and after that 292 patients, who had LDL cholesterol levels≥1.

Safety and tolerability of omecamtiv mecarbil during exercise in patients with ischemic cardiomyopathy and angina.

Objectives: The goal of this study was to assess the safety and tolerability of omecamtiv mecarbil treatment during symptom-limited exercise in patients with ischemic cardiomyopathy and angina. These patients may have increased vulnerability to prolongation of the systolic ejection time.

Background: Omecamtiv mecarbil is a selective cardiac myosin activator that augments cardiac contractility in patients with systolic heart failure through a dose-dependent increase in systolic ejection time.

[Effect of combination therapy with preduktal and prestarium on the left ventricular function in the postinfarction period].

The aim of the study was to estimate the efficiency of combination therapy with Preductal and Prestarium after MI. We investigated 152 patients with acute MI of anterior wall (Q wave) and Heart Failure (II-III class by NYHA). I group included 92 p, which were treated by Preductal (60 mg daily) on the background of the standard therapy.

[Use of Plaferon LB for cardiac preconditioning during experimental ischemia/reperfusion injury in rabbits].

The main goal of research was to study potential of Plaferon LB for cardiac preconditioning during experimental ischemia/reperfusion injury in rabbits. 30 rabbits (2.5-3.

[Effect of perindopril on indices of cardiac function and quality of life in patients with arterial hypertension in regard to age].

At present in the treatment of arterial hypertension the role of angiotensine converting enzyme inhibitors is significant. From this group the most special attention was attracted to peridopril-esbumin. High efficiency of this preparation has been corroborated by numerous controlled, multicentral investigations.

[Changes of immunological and cytogenetic indexes in lymphocytes of patients with bacterial endocarditis under the influence of laser therapy and a hyperbaric oxygen therapy].

The purpose of the present work was the estimation of the therapeutic effect of the soft laser therapy and a hyperbaric oxygen therapy during their inclusion in a therapeutic complex for the treatment of bacterial endocarditis. 30 patients (II group) under our observation have passed the standard basic therapy, and for 45 patients (I group) of different age the intravenous laser and hyperbaric oxygenation were added into the therapeutic complex. The estimation was made by evaluation of immune status and cytogenetic markers before treatment.

Early cardiotoxicity induced by treatment of hematologic malignancies and the risk-factors of its manifestation.

The aim of the study was to determine the incidence of early cardiotoxicity, induced by the treatment of Hemoblastosis and its dependence on the summary dose of antracyclins and other risk-factors (age, sex, pre-existing cardiac diseases). The study revealed that the summary dose of antracyclins is the important risk-factor of cardiotoxicity development. Cardiotoxicity was evident when applying > or =200 mg/m(2) and < or =200 mg/m(2) doses.

[Dynamics of blood viscosity indices in patients with alcoholic myocardiodystrophy].

According to I. V. Strel'chuk's classification, 120 patients with alcoholic myocardiodystrophy induced by stage I-III chronic alcoholism were examined.

[Echography and direct anterograde cholangiography in the diagnosis of mechanical jaundice].

A comparison of the data of echography, percutaneous transhepatic cholangiography and operative findings in 35 patients with obstructive jaundice was made. The complex use of the ultrasonic and radiopaque examination gave more exact information of the place and character of obstructive bile ducts and allowed to choose a rational method of treatment.

[Pathogenesis of diabetic lesions of the myocardium].

On the basis of both literature data and their own observations, the authors suggest the identification of various forms of diabetic cardiopathy in relation to the pathogenetic mechanisms of the development of this complication. The microangiopathic form of diabetic cardiopathy develops as a result of cardiac diabetic microangiopathy. Vegetoneuropathic cardiopathy arises secondary to the impairment of the cardiac performance neural regulation associated with damage to the parasympathetic and/or sympathetic innervation of the heart secondary to diabetic vegetoneuropathy.

[Dynamics of blood antioxidative activity in relation to ECG changes and the course of acute myocardial infarct].

Blood serum antioxidation activity (AOA) was studied by the biophysical method of inhibited electrochemiluminescence in 500 patients with acute myocardial infarction. The degree of increased AOA depends on the size of the affected area. AOA intensity is greater in macrofocal than in microfocal myocardial infarction.