Efficacy of Autologous Cortico-Cancellous Bone Graft and Platelet-Rich Plasma with or without Bio-Oss in Bone Regeneration for Unilateral Alveolar Cleft Defects: A Randomized Controlled Trial.

Introduction: Alveolar cleft grafting is crucial in cleft lip and palate rehabilitation, promoting maxillary continuity and facilitating dental development. While autologous bone grafts are the gold standard, combining them with platelet-rich plasma (PRP) and xenografts like Bio-Oss has the potential to enhance bone regeneration and long-term stability. This study aimed to evaluate the synergistic effects of combining autologous cortico-cancellous bone grafts, PRP, and Bio-Oss in alveolar cleft repair.