Publications by authors named "Meghana A Varde"
Article Synopsis
- - Congenital arhinia-microphthalmos syndrome, or BOSMA syndrome, is a rare condition marked by the complete lack of one or both nasal cavities, along with various facial and eye-related abnormalities.
- - The absence of the nasolacrimal duct leads to issues with tear drainage, manifesting as dilated lacrimal sacs or mucoceles.
- - A team of specialists from several fields, including genetics and surgery, should collaborate early in treatment to ensure comprehensive care for affected individuals.
Purpose: The aim of this study is to analyze the outcome of various techniques for a custom-made iris prosthesis implantation as part of reconstructive anterior segment surgery following traumatic aniridia.
Methods: This retrospective interventional study was done for 6 eyes that received an artificial iris as secondary reconstructive measure for photophobia and unsatisfactory vision following initial globe repair. Different implantation techniques were employed.
A 59-year-old male patient who suffered from a systemically metastasized, large extrascleral uveal melanoma recurrence of the left eye presented with active hemorrhage from the tumor. He had undergone proton beam irradiation for an epithelioid ciliary body melanoma 4 years before presentation and was lost to follow-up. Magnetic resonance angiography showed vascularization of the lesion via the ophthalmic and maxillary artery.
View Article and Find Full Text PDFBackground: Apoptosis is a major mechanism of cell death in glutamate-induced excitotoxicity and caspases as the executors of apoptosis play an important role in the development of various central nervous system and eye diseases. We studied the involvement of certain caspases in excitotoxic retinal ganglion cell death, which was experimentally induced in Brown Norway Rats by application of the glutamate receptor agonist N-methyl-D-aspartate (NMDA).
Methods: Animals were injected intravitreally with one of six caspase inhibitors (against caspases 1, 3, 4, 6, 8 and 9).
Neuroprotective effects of cardiotrophin-like cytokine on retinal ganglion cells.
Graefes Arch Clin Exp Ophthalmol
October 2005
Background: Premature neuronal cell death is a feature of numerous central nervous system and eye diseases, including glaucoma. Neurons (including retinal ganglion cells, RGCs) are protected by several neurotrophic factors, among those the IL-6 family of cytokines. Lately, a novel member of the IL-6 family of cytokines has been identified and cloned.
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