Usefulness of a Novel Mobile Diabetes Prevention Program Delivery Platform With Human Coaching: 65-Week Observational Follow-Up.

Background: It is widely recognized that the prevalence of obesity and comorbidities including prediabetes and type 2 diabetes continue to increase worldwide. Results from a 24-week Diabetes Prevention Program (DPP) fully mobile pilot intervention were previously published showing promising evidence of the usefulness of DPP-based eHealth interventions on weight loss.

Objective: This pilot study extends previous findings to evaluate weight loss results of core (up to week 16) and maintenance (postcore weeks) DPP interventions at 65 weeks from baseline.

Weight loss efficacy of a novel mobile Diabetes Prevention Program delivery platform with human coaching.

Objective: To evaluate the weight loss efficacy of a novel mobile platform delivering the Diabetes Prevention Program.

Research Design And Methods: 43 overweight or obese adult participants with a diagnosis of prediabetes signed-up to receive a 24-week virtual Diabetes Prevention Program with human coaching, through a mobile platform. Weight loss and engagement were the main outcomes, evaluated by repeated measures analysis of variance, backward regression, and mediation regression.

Transgenic mammary epithelial osteopontin (spp1) expression induces proliferation and alveologenesis.

Osteopontin (OPN) Spp1 is involved in differentiation of the mammary gland. We engineered mice to overexpress OPN in mammary epithelium and describe an altered mammary phenotype. Three transgenic (Tg) founder lines FVB/N Tg(MMTV-Opn)((1-3BOR)) were propagated after FVB/NJ pronuclear injections.

Bimalleolar ankle fracture in an adolescent with tillaux fracture.

The purpose of this case report is to present an unusual fracture pattern in an 11-year-old patient characterized by both a predominantly adult fracture type and an exclusively adolescent fracture type. The patient sustained a bimalleolar ankle fracture while sledding. A difficult to detect Tillaux fracture was discovered on preoperative radiograph.