Publications by authors named "Meghan S McQuade"
Article Synopsis
- Researchers found that genetic variants linked to autoimmune diseases are often located in areas that regulate gene activity in CD4 T cells, impacting disease risk through gene regulation changes.
- They analyzed over 18,000 variants associated with autoimmune diseases and identified 545 that influence gene expression, showing a strong connection to causal variants.
- The study demonstrates that these variants work through common regulatory pathways and that they affect gene networks crucial for T cell activation and proliferation, offering insights into how they may contribute to autoimmune disease risk.
