Kaposiform Lymphangiomatosis: Pathologic Aspects in 43 Patients.

Kaposiform lymphangiomatosis is an uncommon generalized lymphatic anomaly with distinctive clinical, radiologic, histopathologic, and molecular findings. Herein, we document the pathology in 43 patients evaluated by the Boston Children's Hospital Vascular Anomalies Center from 1999 to 2020. The most frequent presentations were respiratory difficulty, hemostatic abnormalities, and a soft tissue mass.

Mucocutaneous Adverse Events Associated With Oral Sirolimus for the Treatment of Vascular Anomalies.

This case series examines the clinical spectrum and frequency of mucocutaneous adverse events related to oral sirolimus in populations with vascular anomalies.

Sirolimus as treatment for 19 patients with refractory cervicofacial lymphatic malformation.

Objective: Lymphatic malformations (LMs) are challenging to manage, particularly those involving the cervicofacial region and airway. Traditional therapy is sclerotherapy and/or resection. We aim to establish the emerging therapeutic role of sirolimus.