Publications by authors named "Meghan Lamba"
Sci Transl Med
April 2023
Article Synopsis
- Allogeneic pancreatic islet transplantation has been beneficial for some insulin-dependent diabetes patients, but systemic immunosuppression limits broader use.
- Researchers developed modified human islet cells (HIP p-islets) that lack certain immune markers, allowing them to survive and function well in diabetic mice without triggering an immune response.
- HIP p-islets can be safely eliminated with a specific antibody if necessary, suggesting a promising, no-immunosuppression-required treatment for diabetes patients facing severe hypoglycemia.
