Sentinel lymph node biopsy in desmoplastic melanoma - the percent desmoplastic component matters: A systematic review.

Background: Desmoplastic melanoma (DM) is a less common form of cutaneous melanoma that has been described for decades; however, controversy remains regarding the management and use of sentinel lymph node biopsy (SLNB). The purpose of this study is to identify whether SLNB is indicated in all cases of DM, including the pure subtype.

Methods: A systematic review was conducted using PubMed (with access to MEDLINE) along with the Cochrane Central Register of Controlled Trials from 2001 to 2019.

Non-uremic calciphylaxis in a woman without end-stage renal disease.

A woman in her 60s with a history of lower extremity vascular disease presented with extreme pain and wounds in her legs which had kept her from walking for several weeks. The patient's pain became intolerable throughout her hospital stay despite multiple surgical revascularisations. Biopsy of the patient's calf wounds revealed evidence of calciphylaxis, a diagnosis which corresponds with this patient's extreme pain.