Irgm proteins attenuate inflammatory disease in mouse models of genital infection.

Unlabelled: are obligate intracellular bacterial pathogens that may cause genital pathology via induction of destructive host immune responses. Human-adapted causes inflammatory disease in human hosts but is easily cleared in mice, and mouse-adapted establishes a productive and pathogenic infection in murine hosts. While numerous anti-chlamydial host resistance factors have been discovered in mice and humans alike, little is known about host factors promoting host fitness independent of host resistance.