Associations Between Music and Dance Relationships, Rhythmic Proficiency, and Spatiotemporal Movement Modulation Ability in Adults with and without Mild Cognitive Impairment.

Background: Personalized dance-based movement therapies may improve cognitive and motor function in individuals with mild cognitive impairment (MCI), a precursor to Alzheimer's disease. While age- and MCI-related deficits reduce individuals' abilities to perform dance-like rhythmic movement sequences (RMS)-spatial and temporal modifications to movement-it remains unclear how individuals' relationships to dance and music affect their ability to perform RMS.

Objective: Characterize associations between RMS performance and music or dance relationships, as well as the ability to perceive rhythm and meter (rhythmic proficiency) in adults with and without MCI.

How older adults maintain lateral balance while walking on narrowing paths.

Background: Older adults have difficulty maintaining side-to-side balance while navigating daily environments. Losing balance in such circumstances can lead to falls. We need to better understand how older adults adapt lateral balance to navigate environment-imposed task constraints.

Life-long music and dance relationships inform impressions of music- and dance-based movement therapies in individuals with and without mild cognitive impairment.

Background: No effective therapies exist to prevent degeneration from Mild Cognitive Impairment (MCI) to Alzheimer's disease. Therapies integrating music and/or dance are promising as effective, non-pharmacological options to mitigate cognitive decline.

Objective: To deepen our understanding of individuals' relationships (i.

Associations between music and dance relationships, rhythmic proficiency, and spatiotemporal movement modulation ability in adults with and without mild cognitive impairment.

Background: Personalized dance-based movement therapies may improve cognitive and motor function in individuals with mild cognitive impairment (MCI), a precursor to Alzheimer's disease. While age- and MCI-related deficits reduce individuals' abilities to perform dance-like rhythmic movement sequences (RMS)-spatial and temporal modifications to movement-it remains unclear how individuals' relationships to dance and music affect their ability to perform RMS.

Objective: Characterize associations between RMS performance and music or dance relationships, as well as the ability to perceive rhythm and meter (rhythmic proficiency) in adults with and without MCI.

How Healthy Older Adults Enact Lateral Maneuvers While Walking.

Background: Walking requires frequent maneuvers to navigate changing environments with shifting goals. Humans accomplish maneuvers and simultaneously maintain balance primarily by modulating their foot placement, but a direct trade-off between these two objectives has been proposed. As older adults may rely more on foot placement to maintain lateral balance, they may be less able to adequately adapt stepping to perform lateral maneuvers.

How older adults regulate lateral stepping on narrowing walking paths.

Walking humans often navigate complex, varying walking paths. To reduce falls, we must first determine how older adults purposefully vary their steps in contexts that challenge balance. Here, 20 young (21.

How Healthy Older Adults Enact Lateral Maneuvers While Walking.

Background: Walking requires frequent maneuvers to navigate changing environments with shifting goals. Humans accomplish maneuvers and simultaneously maintain balance primarily by modulating their foot placement, but a direct trade-off between these two objectives has been proposed. As older adults rely more on foot placement to maintain lateral balance, they may be less able to adequately adapt stepping to perform lateral maneuvers.

Rethinking margin of stability: Incorporating step-to-step regulation to resolve the paradox.

Derived from inverted pendulum dynamics, mediolateral Margin of Stability (MoS) is a mechanically-grounded measure of instantaneous frontal-plane stability. However, average MoS measures yield paradoxical results. Gait pathologies or perturbations often induce larger (supposedly "more stable") average MoS, despite clearly destabilizing factors.

Effects of age, physical and self-perceived balance abilities on lateral stepping adjustments during competing lateral balance tasks.

Background: Daily walking paths exhibit varying environment features and require continuous adjustments to locomotor trajectories. Humans maintain lateral balance while navigating paths by modifying stepping in accordance with changing side-to-side path limitations (e.g.

Walking humans trade off different task goals to regulate lateral stepping.

People walk in complex environments where they must adapt their steps to maintain balance and satisfy changing task goals. How people do this is not well understood. We recently developed computational models of lateral stepping, based on Goal Equivalent Manifolds that serve as motor regulation templates, to identify how people regulate walking movements from step-to-step.

How healthy older adults regulate lateral foot placement while walking in laterally destabilizing environments.

Gait variability is generally associated with falls, but specific connections remain disputed. To reduce falls, we must first understand how older adults maintain lateral balance while walking, particularly when their stability is challenged. We recently developed computational models of lateral stepping, based on Goal Equivalent Manifolds, that separate effects of step-to-step regulation from variability.

Comparison of human and guinea pig acetylcholinesterase sequences and rates of oxime-assisted reactivation.

Poisoning via organophosphorus (OP) nerve agents occurs when the OP binds and inhibits the enzyme acetylcholinesterase (AChE). This enzyme is responsible for the metabolism of the neurotransmitter acetylcholine (ACh) which transmits signals between nerves and several key somatic regions. When AChE is inhibited, the signal initiated by ACh is not properly terminated.