Factors Impacting Discharge Destination Following Head and Neck Microvascular Reconstruction.

Objective: Determine which variables impact postoperative discharge destination following head and neck microvascular free flap reconstruction.

Study Design: Retrospective review of prospectively collected databases.

Methods: Consecutive patients undergoing head and neck microvascular free flap reconstruction between January 2010 and December 2019 (n = 1972) were included.

Submandibular gland transfer for the prevention of radiation-induced xerostomia in oropharyngeal cancer: Dosimetric impact in the intensity modulated radiotherapy era.

Background: Submandibular gland (SMG) transfer decreased radiation-associated xerostomia in the 2/3-dimensional radiotherapy era. We evaluated the dosimetric implications of SMG transfer on modern intensity modulated radiotherapy (IMRT) plans.

Methods: Eighteen oropharynx cancer patients underwent SMG transfer followed by IMRT; reoptimized plans using the baseline SMG location were generated.

Age and Comorbidities Impact Medical Complications and Mortality Following Free Flap Reconstruction.

Objective: Determine if age correlated with surgical or medical complications following head and neck free flap reconstruction.

Study Design: Retrospective review of prospectively collected databases.

Methods: Patients undergoing head and neck free flap reconstruction at three tertiary care institutions were included (n = 1972).

Factors impacting successful salvage of the failing free flap.

Background: Understanding factors impacting successful salvage of a compromised free flap.

Methods: Multi-institutional review of free flap reconstructions for head and neck defects (n = 1764).

Results: Free flap compromise rate: 9% (n = 162); 46% salvaged (n = 74).

Functional and survival outcomes in elderly patients undergoing transoral robotic surgery.

Objectives: To determine if elderly patients (≥70 years) have differences in functional and survival outcomes compared to non-elderly patients (<70 years) following transoral robotic surgery.

Materials And Methods: A retrospective cohort study was conducted on patients undergoing robotic surgery for head and neck cancer at a tertiary institution from 2011 to 2016. Functional status was evaluated with diet, enteric feeding status, Functional Oral Intake Scale (FOIS), tracheostomy tube placement, and unplanned readmission.

Factors Associated with Free Flap Failures in Head and Neck Reconstruction.

Objective: To investigate causes of failure of free flap reconstructions in patients undergoing reconstruction of head and neck defects.

Study Design: Case series with chart review.

Setting: Single tertiary care center.

Pathologic Markers in Surgically Treated HPV-Associated Oropharyngeal Cancer: Retrospective Study, Systematic Review, and Meta-analysis.

Objective: Human papillomavirus-associated (HPV) oropharyngeal cancer is a unique clinical entity whose incidence is increasing. It is controversial whether traditional pathologic markers of aggressive head and neck cancer also apply in surgically treated HPV-associated disease.

Study Design: Retrospective study, systematic review, and meta-analysis Data Sources: PubMed and Cochrane review.

Short-term exenatide treatment leads to significant weight loss in a subset of obese women without diabetes.

Objective: To investigate the effect of treatment with the glucagon-like peptide 1 receptor agonist exenatide on weight loss and metabolic parameters in obese nondiabetic women.

Research Design And Methods: Forty-one obese women (aged 48 ± 11 years and BMI 33.1 ± 4.

Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease.

Background & Aims: Fibroblast growth factor 21 (FGF21) is an hepatic protein that plays a critical role in metabolism, stimulating fatty acid oxidation in liver and glucose uptake in fat. Systemic administration to obese rodents and diabetic monkeys leads to improved glucose homeostasis and weight loss. In rodents, FGF21 increases with fasting and consumption of a ketogenic diet (KD).