Publications by authors named "Meghan C H Ozcan"
Article Synopsis
- The study aims to investigate the long-term reproductive effects on female offspring exposed to taxanes (docetaxel and paclitaxel) in utero, focusing on their ovarian reserve and fertility potential.
- Pregnant mice were administered either saline, docetaxel, or paclitaxel, and their daughters were later analyzed for ovarian health, hormone levels, and reproductive outcomes.
- Results show that in utero taxane exposure leads to ovarian toxicity in the daughters, characterized by increased follicular abnormalities and alterations in hormone levels, which could impact their fertility.
The regulation of protein turnover by the unique deubiquitinating enzyme ubiquitin C-terminal hydrolase L1 (UCHL1) is only seen in oocytes, spermatogonia, and neurons. Our objective was to investigate variation in expression of UCHL1 across fetal maturation of oocytes that result in lifelong ovarian reserve. We performed a retrospective cohort study of 25 fetal autopsy specimens from 21 to 36 weeks.
View Article and Find Full Text PDFUbiquitin C-terminal hydrolase L1 (UCHL1) is a de-ubiquitinating enzyme enriched in neuronal and gonadal tissues known to regulate the cellular stores of mono-ubiquitin and protein turnover. While its function in maintaining proper motor neuron function is well established, investigation into its role in the health and function of reproductive processes is only just beginning to be studied. Single-cell-sequencing analysis of all ovarian cells from the murine perinatal period revealed that Uchl1 is very highly expressed in the developing oocyte population, an observation which was corroborated by high levels of oocyte-enriched UCHL1 protein expression in oocytes of all stages throughout the mouse reproductive lifespan.
View Article and Find Full Text PDFObjective: To evaluate the fertility outcomes of salpingectomy compared with those of salpingostomy among patients treated for tubal ectopic pregnancies, including a separate analysis of women with risk factors along with a review of the surgical technique.
Data Sources: Systematic review and meta-analysis from 1990 to the present through PubMed, Embase, CINAHL, and Ovid MEDLINE. The search string included "tubal pregnancy" or "ectopic" as well as "salpingectomy" and various terms describing salpingotomy.