Publications by authors named "Meghan B DeCelie"
Gastrointestinal fungal dysbiosis is a hallmark of several diseases marked by systemic immune activation. Whether persistent pathobiont colonization during immune alterations and impaired gut barrier function has a durable impact on host immunity is unknown. We found that elevated levels of Candida albicans immunoglobulin G (IgG) antibodies marked patients with severe COVID-19 (sCOVID-19) who had intestinal Candida overgrowth, mycobiota dysbiosis and systemic neutrophilia.
View Article and Find Full Text PDFAberrant CD4 T cell reactivity against intestinal microorganisms is considered to drive mucosal inflammation in inflammatory bowel diseases. The disease-relevant microbial species and the corresponding microorganism-specific, pathogenic T cell phenotypes remain largely unknown. In the present study, we identified common gut commensal and food-derived yeasts, as direct activators of altered CD4 T cell reactions in patients with Crohn's disease (CD).
View Article and Find Full Text PDFArticle Synopsis
- The mycobiota, the fungal component of gut microbiota, plays a crucial role in immune regulation and is linked to diseases like inflammatory bowel disease (IBD).
- Researchers developed a platform to analyze mycobiome functionality at an individual patient level through advanced techniques such as fungal strain editing and immune response assays.
- They found diverse Candida albicans strains in IBD patients that can trigger inflammation and disease symptoms by damaging immune cells, revealing the importance of strain-specific interactions and offering potential new diagnostic and therapeutic approaches for inflammatory diseases.