Publications by authors named "Meghan A Lockard"
The molecular and functional conservation of oxytocin-related neuropeptides in behavior is striking. In animals separated by at least 600 million years of evolution, from roundworms to humans, oxytocin homologs play critical roles in the modulation of reproductive behavior and other biological functions. Here, we review the roles of oxytocin in invertebrate behavior from an evolutionary perspective.
View Article and Find Full Text PDFMonitoring protein-protein interactions in living cells is key to unraveling their roles in numerous cellular processes and various diseases. Previously described split-GFP based sensors suffer from poor folding and/or self-assembly background fluorescence. Here, we have engineered a micro-tagging system to monitor protein-protein interactions in vivo and in vitro.
View Article and Find Full Text PDFArticle Synopsis
- Researchers developed a new method to identify E. coli that produce soluble proteins and stable protein complexes using a fluorescent tagging system.* -
- The screening process involves partially lysing colonies, allowing released fluorescent proteins to be captured on specialized beads, providing insights into both protein expression and solubility.* -
- This technique successfully identified clones from a human protein library, particularly those expressing full-length domains and stable protein complexes, without the need for creating extra plates.*