Publications by authors named "Meghan A Koop"

Pre-clinical evidence shows that neuropathy is associated with complex neuroimmune responses, which in turn are associated with increased intensity and persistence of neuropathic pain. Routine exercise has the potential to mitigate complications of future nerve damage and persistence of pain through neuroimmune regulation. This systematic review aimed to explore the effect of pre-injury exercise on neuroimmune responses, and other physiological and behavioural reactions following peripheral neuropathy in animals.

View Article and Find Full Text PDF
Article Synopsis
  • The study analyzed presentations from the 12th EFIC congress to explore geographical and gender differences in the biopsychosocial approach to pain research across European countries.
  • Findings showed three distinct clusters of countries based on their focus: some prioritized non-biomedical approaches, others had a balance, and some leaned heavily towards biomedical research.
  • Women made more presentations overall and focused more on non-biomedical topics, while men were more likely to present on biomedical issues, indicating a gender disparity in research orientation.
View Article and Find Full Text PDF

Background: Increasing pre-clinical evidence suggests that aerobic exercise positively modulates neuroimmune responses following traumatic nerve injury. However, meta-analyses on neuroimmune outcomes are currently still lacking. This study aimed to synthesize the pre-clinical literature on the effects of aerobic exercise on neuroimmune responses following peripheral nerve injury.

View Article and Find Full Text PDF

Neuroimmune responses remain understudied in people with neck pain. This study aimed to (1) compare a broad range of systemic neuroimmune responses in people with non-specific neck pain ( = 112), cervical radiculopathy ( = 25), and healthy participants ( = 23); and (2) explore their associations with clinical, psychological and lifestyle factors. Quantification of systemic neuroimmune responses involved serum and evoked-release levels of inflammatory markers, and characterization of white blood cell phenotypes.

View Article and Find Full Text PDF

Objective: The association between low-grade systemic inflammation and musculoskeletal pain may be influenced by multiple factors. However, little is known about the relative importance of these factors, and few studies account for them. This Delphi study aimed to reach consensus on the most important confounders which influence the association between low-grade systemic inflammation and musculoskeletal pain.

View Article and Find Full Text PDF