Publications by authors named "Megha Roy"

Article Synopsis
  • DNA double-strand break (DSB) repair starts with DNA end resection, where the 5'-ended strands at break sites are carefully degraded, a process aided by the BRCA1-BARD1 protein complex.
  • BRCA1-BARD1 not only promotes this resection process by activating specific nucleases (EXO1 and DNA2) but also works together with other proteins (like MRE11-RAD50-NBS1 and phosphorylated CtIP) to form the BRCA1-C complex, enhancing repair efficiency.
  • Interestingly, while BRCA1-BARD1 supports resection, it also plays a protective role during DNA replication stress by working with the
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, an important food-borne zoonotic parasite, poses a worldwide public health hazard. Domestic pigs are considered one of the main intermediate hosts in the zoonotic transmission of . To date, seroepidemiological information on in domestic pigs in India is very scarce, and there are no reports of occupational hazards to pig farmers in this country.

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Toxoplasma gondii and Neospora caninum are genetically related cyst-forming protozoan parasites that cause reproductive failures in ruminants. Given the limited information on the epidemiology of these infections in goats in India, the study aimed to estimate the seroprevalence, assess antibody cross-reactivity for diagnosis, and identify associated risk factors. A total of 695 sera were evaluated for antibodies to T.

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Microtubules (MTs) form physiologically important cytoskeletal structures that are assembled by tubulin polymerization in nucleation- and guanosine triphosphate (GTP)-dependent manner. GTP hydrolysis competes with the addition of monomers, to determine the GTP-cap size, and the onset of shrinkage, which alternates with growth. Multiple theoretical models of MT polymerization dynamics have been reconciled to the kinetics of animal brain tubulins, but more recently, rapid kinetics seen in Arabidopsis tubulin polymerization suggest the need to sample a wider diversity in tubulin polymerization kinetics and reconcile it to theory.

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