PET Imaging Using 89Zr-Labeled StarPEG Nanocarriers Reveals Heterogeneous Enhanced Permeability and Retention in Prostate Cancer.

The enhanced permeability and retention (EPR) effect controls passive nanodrug uptake in tumors and may provide a high tumor payload with prolonged retention for cancer treatment. However, EPR-mediated tumor uptake and distribution vary by cancer phenotype. Thus, we hypothesized that a companion PET imaging surrogate may benefit EPR-mediated therapeutic drug delivery.

Fluorescent Sensors for Tetracycline Detection in Aqueous Medium: A Mini-Review.

Tetracycline (TC) is a commonly used antibiotic in human therapy and animal husbandry. Public concerns about TC residues inflated due to their negative impact on the environment, food, and human health concerns. To ensure human health and safety, there is a need for fluorogenic chemosensors that can easily detect TC antibiotics with high selectivity and sensitivity in the aqueous medium.

Fluorescent Probes for Detection of Environmental Contaminants (NACs & VOCs): Probe Design from a Supramolecular Perspective.

Fresh air and clean water are essential constituents for the human population as well as for fauna and flora. Owing to the extreme toxicity of NACs and VOCs in physiological systems and their widespread presence in the environment, serious mitigation is required. The innovation of chemosensors for these two types of harmful organic contaminants (NACs i.

Quinoxaline-based membrane-targeting therapeutic material: Implications in rejuvenating antibiotic and curb MRSA invasion in an in vitro bone cell infection model.

Manifestation of resistance in methicillin-resistant Staphylococcus aureus (MRSA) against multiple antibiotics demands an effective strategy to counter the menace of the pathogen. To address this challenge, the current study explores quinoxaline-based synthetic ligands as an adjuvant material to target MRSA in a combination therapy regimen. Amongst the tested ligands (C1-C4), only C2 was bactericidal against the MRSA strain S.

Quinoxaline-probe embedded injectable fluorogenic hydrogels: Comparative detection of mesitylene in guar gum and i-carrageenan hydrogels.

The innovation of novel chemosensor probes for the recognition of trace volatile organic compounds is critical due to their hazardous effect on the environment and human health. A nitro-group integrated quinoxaline probe with a profound discriminative fluorescence 'turn-on' response to mesitylene was fabricated into guar gum and i-carrageenan, two biopolymer-based hydrogel matrices, to develop compact, portable fluorogenic hydrogel sensors and assess their fluorescence properties. A comparative characterization-based analysis of native, probe-associated, and probe-analyte-associated hydrogels, (comprising of FT-IR, XRD, TGA) was investigated to ascertain the overall compatibility of the hydrogel-based sensors for use as a smart rapid detection tool.

Amine-incorporated quinoxaline based fluorescent sensor for detection of trace water: Solvent influenced self-assembly.

Polarity is a complex parameter, with important effect in chemistry and biology. In recent years, polarity exploration attracted more and more attention hence, it's of great importance to exploit new methods for polarity determination. A novel class of long, coplanar, and amine incorporated electron-rich quinoxaline scaffold(L) furnished maximum solvatochromic effect and large Stokes shift and was chosen to determine water content in organic solvents e.

Supramolecular self-assembly of a nitro-incorporating quinoxaline framework: insights into the origin of fluorescence turn-on response towards the benzene group of VOCs.

Hazardous volatile organic compounds (VOCs) can significantly impact human health and the environment. Hence, the detection of VOCs is of foremost importance. A quinoxaline-based fluorimetric probe (1) unveils a notable "turn-on" fluorescence response towards mesitylene in the presence of other VOCs and common interfering ions in aqueous media.