Publications by authors named "Meggin Costa"
Article Synopsis
- The study aimed to create an animal model that distinguishes between joint instability and inflammation's effects on posttraumatic osteoarthritis (PTOA), proposing that their modified drilling procedure would induce cartilage damage and inflammation without altering gait.
- Twenty-four Yucatan minipigs were divided into two groups, one undergoing the modified intra-articular drilling (mIAD) and the other serving as a sham control, with outcomes assessed through various evaluations 15 weeks post-surgery.
- Results showed that mIAD knees had significantly more cartilage damage and inflammation markers than controls, but no notable changes in gait mechanics, suggesting this model is useful for studying inflammatory roles in PTOA and developing relevant therapies.
Article Synopsis
- - The study investigates how neuromuscular function could influence the risk of posttraumatic osteoarthritis (PTOA) in patients who have undergone anterior cruciate ligament (ACL) reconstruction, highlighting the need for effective analysis tools.
- - Researchers compared the muscle activity patterns of ACL-reconstructed patients to healthy controls using EMG recording during a hop activity, finding that the muscle activation strategies of ACLR patients were globally adapted and symmetrical but differed significantly from those of healthy individuals.
- - The results indicated that smaller thigh muscle girth in the affected leg was the strongest predictor of worse MRI outcomes related to osteoarthritis, suggesting a potential link between muscle activation patterns and PTOA risk that warrants further investigation.
Background: Quantitative magnetic resonance imaging (qMRI) methods were developed to establish the integrity of healing anterior cruciate ligaments (ACLs) and grafts. Whether qMRI variables predict risk of reinjury is unknown.
Purpose: To determine if qMRI measures at 6 to 9 months after bridge-enhanced ACL restoration (BEAR) can predict the risk of revision surgery within 2 years of the index procedure.
Article Synopsis
- The study aimed to evaluate the effects of intraarticular injections of an extracellular matrix and blood composite (ECM-B) on post-operative gait in guinea pigs with idiopathic osteoarthritis (OA) while monitoring potential side effects.
- Twenty-one Dunkin Hartley Guinea pigs received ECM-B injections and were assessed for gait changes along with knee evaluations at various weeks, compared against a control group given saline injections.
- Results indicated a significant improvement in the ECM-B group's hind limb base of support at Week 4, but this effect diminished by Week 8, with no harmful effects observed on cartilage or lymph nodes.
Background: Anterior cruciate ligament (ACL) revision surgery is challenging for both patients and surgeons. Understanding the risk factors for failure after bridge-enhanced ACL restoration (BEAR) may help with patient selection for ACL restoration versus ACL reconstruction.
Purpose: To identify the preoperative risk factors for ACL revision surgery within the first 2 years after BEAR.
Background: The initial graft tension applied during anterior cruciate ligament (ACL) graft fixation may promote posttraumatic osteoarthritis (PTOA).
Purpose/hypothesis: This study sought to assess the effect of initial graft tension and patient sex on PTOA outcomes at 10 to 12 years after ACL reconstruction (ACLR). The hypothesis was that there would be no group- or sex-based differences in outcomes.
Collagen organization of the anterior cruciate ligament (ACL) can be evaluated using T * relaxometry. However, T * mapping requires manual image segmentation, which is a time-consuming process and prone to inter- and intra- segmenter variability. Automating segmentation would address these challenges.
View Article and Find Full Text PDFQuantitative magnetic resonance imaging has been used to evaluate the structural integrity of knee joint structures. However, variations in acquisition parameters between scanners pose significant challenges. Understanding the effect of small differences in acquisition parameters for quantitative sequences is vital to the validity of cross-institutional studies, and for the harmonization of large, heterogeneous datasets to train machine learning models.
View Article and Find Full Text PDFAnterior cruciate ligament injuries result in posttraumatic osteoarthritis in the medial compartment of the knee, even after surgical treatment. How the chondrocyte distribution within the articular cartilage changes early in this process is currently unknown. The study objective was to investigate the chondrocyte distribution within the medial femoral condyle after an anterior cruciate ligament transection in a preclinical model.
View Article and Find Full Text PDFThe roles that cytokines and matrix metalloproteinases play in the onset and progression of posttraumatic osteoarthritis (PTOA) remain a topic of debate. The study objective was to evaluate the concentrations of these inflammatory mediators during the development of mild to moderate PTOA in the porcine anterior cruciate ligament (ACL) surgical model. We hypothesized that there would be more animals with detectable mediators in the pigs that develop moderate PTOA (those receiving ACL reconstruction or untreated ACL transection) compared to those that develop mild PTOA (those receiving scaffold-enhanced ACL repair).
View Article and Find Full Text PDFBridge-Enhanced Anterior Cruciate Ligament Repair Leads to Greater Limb Asymmetry and Less Cartilage Damage Than Untreated ACL Transection or ACL Reconstruction in the Porcine Model.
Am J Sports Med
March 2021
Background: The extent of posttraumatic osteoarthritis (PTOA) in the porcine anterior cruciate ligament (ACL) transection model is dependent on the surgical treatment selected. In a previous study, animals treated with bridge-enhanced ACL repair using a tissue-engineered implant developed less PTOA than those treated with ACL reconstruction (ACLR). Alterations in gait, including asymmetric weightbearing and shorter stance times, have been noted in clinical studies of subjects with osteoarthritis.
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