Population trends in adult strabismus surgery.

Objective: To review the trends in adult strabismus procedures in Ontario from 2000-2013.

Design: Population-based, retrospective data analysis.

Participants: All patients 18 years or older who underwent a strabismus related procedure in Ontario and all ophthalmologists who performed these procedures from 2000-2013.

The Cannabinoids ΔTHC, CBD, and HU-308 Act via Distinct Receptors to Reduce Corneal Pain and Inflammation.

Corneal injury can result in dysfunction of corneal nociceptive signaling and corneal sensitization. Activation of the endocannabinoid system has been reported to be analgesic and anti-inflammatory. The purpose of this research was to investigate the antinociceptive and anti-inflammatory effects of cannabinoids with reported actions at cannabinoid 1 (CBR) and cannabinoid 2 (CBR) receptors and/or noncannabinoid receptors in an experimental model of corneal hyperalgesia.

Trends in pediatric strabismus surgery in the new millennium: influence of funding and perceived benefits of surgery.

Objective: The rate of strabismus surgery was previously reported to be decreasing in the United Kingdom and Ontario. Data on the influence of government funding on surgical trends and recent population trends for surgery in pediatric patients in Canada are limited. This study aims to analyze the trend in pediatric strabismus procedures in Ontario from 2000 to 2013.

Turning Down the Thermostat: Modulating the Endocannabinoid System in Ocular Inflammation and Pain.

The endocannabinoid system (ECS) has emerged as an important regulator of both physiological and pathological processes. Notably, this endogenous system plays a key role in the modulation of pain and inflammation in a number of tissues. The components of the ECS, including endocannabinoids, their cognate enzymes and cannabinoid receptors, are localized in the eye, and evidence indicates that ECS modulation plays a role in ocular disease states.

A GPR18-based signalling system regulates IOP in murine eye.

Background And Purpose: GPR18 is a recently deorphaned lipid receptor that is activated by the endogenous lipid N-arachidonoyl glycine (NAGly) as well the behaviourally inactive atypical cannabinoid, abnormal cannabidiol (Abn-CBD). The presence and/or function of any GPR18-based ocular signalling system remain essentially unstudied. The objectives of this research are: (i) to determine the disposition of GPR18 receptors and ligands in anterior murine eye, (ii) examine the effect of GPR18 activation on intraocular pressure (IOP) in a murine model, including knockout mice for CB₁, CB₂ and GPR55.