Publications by authors named "Megan Woodberry"
Glioblastomas are hierarchically organised tumours driven by glioma stem cells that retain partial differentiation potential. Glioma stem cells are maintained in specialised microenvironments, but whether, or how, they undergo lineage progression outside of these niches remains unclear. Here we identify the white matter as a differentiative niche for glioblastomas with oligodendrocyte lineage competency.
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- Sympathetic nervous system and immune cell interactions are crucial for regulating metabolism, particularly how macrophages influence obesity through the activation of brown adipose tissue (BAT) and the "beiging" of white adipose tissue (WAT).
- A new mouse model lacking Irs2 in specific immune cells showed resistance to obesity and better glucose control on a high-fat diet due to increased BAT activity and WAT beiging.
- The study revealed that while macrophages don’t produce catecholamines, the Irs2-deficient mice had increased sympathetic nerve density and catecholamine levels in adipose tissue, suggesting a novel macrophage signaling pathway that could inform obesity treatments.