Neurogranin regulates calcium-dependent cardiac hypertrophy.

Intracellular Ca-calmodulin (CaM) signaling plays an important role in Ca-CaM-dependent kinase (CaMKII) and calcineurin (CaN)-mediated cardiac biology. While neurogranin (Ng) is known as a major Ca-CaM modulator in the brain, its pathophysiological role in cardiac hypertrophy has never been studied before. In the present study, we report that Ng is expressed in the heart and depletion of Ng dysregulates Ca homeostasis and promotes cardiac failure in mice.