Publications by authors named "Megan Sandman"
Background: Evaluating effects of different macronutrient diets in randomized trials requires well defined infrastructure and rigorous methods to ensure intervention fidelity and adherence.
Methods: This controlled feeding study comprised two phases. During a Run-in phase (14-15 weeks), study participants (18-50 years, BMI, ≥27 kg/m) consumed a very-low-carbohydrate (VLC) diet, with home delivery of prepared meals, at an energy level to promote 15 ± 3% weight loss.
A research team from Boston Children's Hospital and Harvard Medical School conducted a community-based feeding study in collaboration with Framingham State University (FSU) and Sodexo, the food service contractor at FSU. The study was a randomized controlled trial, implemented on the FSU campus. For the final year of the study, a satellite feeding site was established at Assabet Valley Regional Technical High School.
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- The study investigates the long-term effects of different carbohydrate-to-fat ratios in diets on maintaining weight loss among individuals who are overweight or obese after an initial weight loss period.
- 164 participants aged 18 to 65 were randomly assigned to one of three controlled diets (high-carb, moderate-carb, low-carb) for 20 weeks, following a standardized weight loss phase.
- Primary outcomes measured included total energy expenditure and secondary outcomes involved resting energy, physical activity, chronic disease risk, and metabolism-related factors to understand how the diet ratio affected weight maintenance.