Publications by authors named "Megan S Griffin"
Article Synopsis
- Blood clots in zebrafish consist mainly of red blood cells and platelets, and the study aims to compare their clot formation with that in mammals.
- The research utilized transgenic zebrafish and advanced imaging techniques to analyze blood clot structure and the role of thrombocytes in clotting, revealing similar structures between fish and mammalian thrombi.
- Findings indicate that clot formation can occur without blood cells and suggest that there is evolutionary conservation in clotting processes, which may imply that mammals could also form clots without circulating cells.
Congenital erythropoietic porphyria (CEP) is a rare genetic disorder leading to accumulation of uro/coproporphyrin-I in tissues due to inhibition of uroporphyrinogen-III synthase. Clinical manifestations of CEP include bone fragility, severe photosensitivity and photomutilation. Currently there is no specific treatment for CEP, except bone marrow transplantation, and there is an unmet need for treating this orphan disease.
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