Publications by authors named "Megan S Crotts"
Article Synopsis
- Metastatic melanoma often avoids current treatments that trigger cell death through apoptosis, suggesting the need for therapies that target different cell-death pathways.
- Doramectin, previously effective in neuroblastoma by promoting autophagy, was tested on B16F10 melanoma cells to see if it induces similar effects.
- Results revealed that doramectin decreased cell growth and caused apoptotic characteristics in melanoma cells, but increased autophagy wasn't detected, leading to the conclusion that doramectin may offer a new mechanism for inducing cell death in melanoma treatment.
Shikonin Causes Non-apoptotic Cell Death in B16F10 Melanoma.
Anticancer Agents Med Chem
September 2023
Background: Melanoma treatment is highly resistant to current chemotherapeutic agents. Due to its resistance towards apoptotic cell death, non-apoptotic cell death pathways are sought after.
Objective: We investigated a Chinese herbal medicine, shikonin, and its effect on B16F10 melanoma cells in vitro.
Patients with uncontrolled epilepsy have a high risk of sudden unexpected death in epilepsy (SUDEP). Seizure-induced respiratory arrest (S-IRA) is thought to be the determining cause of death in many cases of SUDEP. The goal of the present study was to use Scn1a (Dravet Syndrome, DS) and DBA/1 mice to determine: (1) the effect of a ketogenic diet (KD) on S-IRA and (2) the relationship between serum ketones and the protective effect of a KD.
View Article and Find Full Text PDFSudden unexpected death in epilepsy (SUDEP) is a major cause of mortality in patients with drug-resistant epilepsy. Most SUDEP cases occur in bed at night and are preceded by a generalized tonic-clonic seizure (GTCS). Dravet syndrome (DS) is a severe childhood-onset epilepsy commonly caused by mutations in the gene.
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