Publications by authors named "Megan Quinlan-Waters"
Objective: Prognostic factors associated with medication discontinuation in children with juvenile dermatomyositis (JDM) remain largely elusive. We aim to identify the predictors of medication-free remission (MFR) in children with JDM.
Methods: In this retrospective study, patients diagnosed with JDM according to Peter & Bohan criteria and followed for ≥18 months at a tertiary care center from 2006 through 2022 were included.
Background: Uveitis is an inflammatory ocular disease secondary to disruption of the retinal pigmented epithelium (RPE) and blood retinal barrier (BRB). Known clinical factors do not accurately predict uveitis risk in Juvenile Idiopathic Arthritis (JIA). Tear fluid is easily obtained for biomarker study.
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- Chronic anterior uveitis (CAU) can cause serious eye problems, so doctors created treatment plans to help kids with it.
- The study looked at how these treatment plans worked for kids with a type of arthritis-related eye condition, tracking their medicine and eye health over time.
- Results showed that most kids had good control of their uveitis after six months, and both treatment plans were successfully used in real-life doctor visits.
Article Synopsis
- Autosomal dominant neovascular inflammatory vitreoretinopathy (NIV) is a rare adult condition caused by CAPN5 gene mutations, which leads to eye inflammation; this study focuses on its treatment in children.* -
- Eight children were studied, receiving systemic immunosuppression after being diagnosed with NIV; although they initially responded to glucocorticoids, the effects were not sustained, and other treatments like methotrexate and infliximab were ineffective.* -
- The findings suggest that systemic therapies did not control the disease in these pediatric patients, highlighting the need for more research on effective long-term treatments for NIV.*