11-Oxygenated Androgen Metabolite Concentrations Are Affected by Pubertal Progression and Obesity.

Introduction: 11-oxygenated C19 steroids (11-oxyandrogens) have been shown to rise during adrenarche and remain higher throughout adulthood than in early childhood. The patterns of circulating 11-oxyandrogens throughout normal puberty have not yet been described.

Methods: We conducted a secondary analysis of healthy youth participants, both males and females, enrolled in six prior endocrine studies (N = 249).

Testosterone, obesity and insulin resistance in young males: evidence for an association between gonadal dysfunction and insulin resistance during puberty.

Objective: To assess the relationships among obesity, insulin sensitivity, and testosterone in pubertal boys.

Participants: This study included 20 lean, obese, and type 2 diabetic (T2DM) males, the majority of whom underwent a hyperinsulinemic-euglycemic clamp (n=16).

Methods: Glucose disposal (M value), serum testosterone, and body mass index (BMI) z-score were measured.