Temporal summation of pain in sickle cell disease: comparison of adolescents and young adults with chronic vs. infrequent pain.

Objective: This study examined the role of central sensitization in the experience of pain among adolescents and young adults with the most severe genotypes of sickle cell disease (SCD). We hypothesized that adolescents and young adults with chronic SCD pain would demonstrate a higher perceptual response to repeated stimulation of identical intensity (i.e.