Publications by authors named "Megan Marcotulli"
J Immunother Cancer
February 2021
Article Synopsis
- Immune checkpoint inhibitors (ICIs) are being explored for use after allogeneic hematopoietic stem cell transplantation (alloHCT) to address immune dysfunction, but they may increase the risk of graft-versus-host disease (GVHD).
- A study involving 21 patients with relapsed acute myeloid leukemia or myelodysplastic syndromes found that the type of GVHD prophylaxis significantly influenced the incidence of acute GVHD following ICI therapy.
- Patients who received post-transplantation cyclophosphamide (PTCy) had a shorter median time to start ICI therapy and a notably lower risk of developing acute GVHD compared to those who did not receive PTCy, suggesting PTCy may
