Publications by authors named "Megan M Bernath"
Cerebrovascular injury is a potentially devastating outcome following craniofacial trauma. Interventional radiologists play an important role in detecting, grading, and treating the different types of vascular injury. Computed tomography angiography plays a significant role in the detection of these injuries.
View Article and Find Full Text PDFObjective: To investigate the association of triglyceride (TG) principal component scores with Alzheimer disease (AD) and the amyloid, tau, neurodegeneration, and cerebrovascular disease (A/T/N/V) biomarkers for AD.
Methods: Serum levels of 84 TG species were measured with untargeted lipid profiling of 689 participants from the Alzheimer's Disease Neuroimaging Initiative cohort, including 190 cognitively normal older adults (CN), 339 with mild cognitive impairment (MCI), and 160 with AD. Principal component analysis with factor rotation was used for dimension reduction of TG species.
Article Synopsis
- Accumulating evidence suggests that dysfunction in the autophagic-lysosomal pathway plays a crucial role in Parkinson's disease (PD), primarily due to the buildup of neurotoxic α-synuclein associated with autophagy defects.
- A murine model of Kufor-Rakeb syndrome (KRS), caused by mutations in the ATP13A2 gene, reveals specific issues in protein trafficking and motor dysfunction that occur with age, alongside neurodegenerative changes.
- Crucially, findings indicate that the neurotoxic effects related to endolysosomal dysfunction can occur independently of α-synuclein, challenging previous assumptions about their relationship in the context of PD.