The Miranda penalty: Inferring guilt from suspects' silence.

Objective: Despite the risks inherent to custodial police interrogation, criminal suspects may waive their rights and submit to police questioning in fear that exercising their rights or remaining silent will make them appear guilty. We tested whether such a penalty exists.

Hypotheses: We predicted that people would perceive suspects who invoke their rights or sit in silence during an interrogation as more likely to be guilty than those who waive their rights.

A randomised controlled trial of a digital intervention (Renewed) to support symptom management, wellbeing and quality of life in cancer survivors.

Background: Many cancer survivors following primary treatment have prolonged poor quality of life.

Aim: To determine the effectiveness of a bespoke digital intervention to support cancer survivors.

Design: Pragmatic parallel open randomised trial.

Cost-effectiveness of Spironolactone for Adult Female Acne (SAFA): economic evaluation alongside a randomised controlled trial.

Objective: This study aims to estimate the cost-effectiveness of oral spironolactone plus routine topical treatment compared with routine topical treatment alone for persistent acne in adult women from a British NHS perspective over 24 weeks.

Design: Economic evaluation undertaken alongside a pragmatic, parallel, double-blind, randomised trial.

Setting: Primary and secondary healthcare, community and social media advertising.

Extracting the truth through chemical analyses: Early life histories of Victorian-era dental patients in Aotearoa New Zealand.

Objectives: There are few bioarcheological analyses of life experiences in colonial period Aotearoa New Zealand, despite this being a time of major adaptation and social change. In our study, early life histories are constructed from multi-isotope and enamel peptide analysis of permanent first molars associated with Victorian era dental practices operating between AD 1881 and 1905 in Invercargill. Chemical analyses of the teeth provide insight into the childhood feeding practices, diet, and mobility of the people who had their teeth extracted.

Evaluating atezolizumab in patients with urinary tract squamous cell carcinoma (AURORA): study protocol for a single arm, open-label, multicentre, phase II clinical trial.

Background: Bladder and urinary tract cancers account for approximately 21,000 new diagnoses and 5,000 deaths annually in the UK. Approximately 90% are transitional cell carcinomas where advanced disease is treated with platinum based chemotherapy and PD-1/PD-L1 directed immunotherapy. Urinary tract squamous cell carcinoma (UTSCC) accounts for about 5% of urinary tract cancers overall making this a rare disease.

Effectiveness of spironolactone for women with acne vulgaris (SAFA) in England and Wales: pragmatic, multicentre, phase 3, double blind, randomised controlled trial.

Objective: To assess the effectiveness of oral spironolactone for acne vulgaris in adult women.

Design: Pragmatic, multicentre, phase 3, double blind, randomised controlled trial.

Setting: Primary and secondary healthcare, and advertising in the community and on social media in England and Wales.

Counterintuitive race effects in legal and nonlegal contexts.

Objective: Despite documented racial disparities in all facets of the criminal justice system, recent laboratory attempts to investigate racial bias in legal settings have produced null effects or racial-bias reversals. These counterintuitive findings may be an artifact of laboratory participants' attempts to appear unprejudiced in response to social norms that proscribe expressions of racial bias against Black individuals. Furthermore, given pervasive stereotypes linking Black people with crime and heightened attention to issues of racial injustice in the legal system, laboratory participants may be especially likely to attempt to appear unprejudiced in studies examining judgments of Black individuals in legal as opposed to nonlegal contexts.

The role of social desirability and establishing nonracist credentials on mock juror decisions about Black defendants.

Objective: Recently, experimental work on racial bias in legal settings has diverged from real-world field data demonstrating racial disparities, instead often producing null or potential overcorrection effects favoring Black individuals over White individuals. We explored the role of social desirability in these counterintuitive effects and tested whether allowing participants to establish nonracist moral credentials increased their willingness to convict a Black defendant.

Hypotheses: We predicted that establishing nonracist moral credentials would increase convictions of Black defendants-especially for participants likely to harbor racial bias and external motivation to control it.

Evaluating the mechanisms of social cognition intervention in schizophrenia: A proof-of-concept trial.

Background: Social cognition interventions have shown promise for improving social functioning in people with schizophrenia. However, it is unclear how changes in social cognition affect social functioning. This study evaluates the impact of a social cognition intervention (GRASP - GRoup trAining for Social skills in Psychosis) on social cognition and social functioning outcomes and explores how two mechanisms, affect and physiological arousal, may drive changes.

An Open Label, Adaptive, Phase 1 Trial of High-Dose Oral Nitazoxanide in Healthy Volunteers: An Antiviral Candidate for SARS-CoV-2.

Repurposing approved drugs may rapidly establish effective interventions during a public health crisis. This has yielded immunomodulatory treatments for severe coronavirus disease 2019 (COVID-19), but repurposed antivirals have not been successful to date because of redundancy of the target in vivo or suboptimal exposures at studied doses. Nitazoxanide is a US Food and Drug Administration (FDA) approved antiparasitic medicine, that physiologically-based pharmacokinetic (PBPK) modeling has indicated may provide antiviral concentrations across the dosing interval, when repurposed at higher than approved doses.

Using wearable technology to detect the autonomic signature of illness severity in schizophrenia.

Introduction: Research suggests that people with schizophrenia have autonomic dysfunctions. These have been linked to functioning problems, symptoms and considered a risk factor for illness chronicity. The aim of this study is to introduce a new Mobile Health (mHealth) method using wearable technology to assessing autonomic activity in people's everyday life.

Social cognition interventions for people with schizophrenia: a systematic review focussing on methodological quality and intervention modality.

Background: People with a diagnosis of schizophrenia have significant social and functional difficulties. Social cognition was found to influences these outcomes and in recent years interventions targeting this domain were developed. This paper reviews the existing literature on social cognition interventions for people with a diagnosis of schizophrenia focussing on: i) comparing focussed (i.

The beat of social cognition: Exploring the role of heart rate variability as marker of mentalizing abilities.

There is a long-standing debate on the influence of physiological signals on social behavior. Recent studies suggested that heart rate variability (HRV) may be a marker of social cognitive processes. However, this evidence is preliminary and limited to laboratory studies.