STAT6 Blockade Abrogates -Induced Eosinophilic Chronic Rhinosinusitis and Asthma, A Model of Unified Airway Disease.

Unified airway disease, including concurrent asthma and chronic rhinosinusitis (CRS), is a common, but poorly understood disorder with no curative treatment options. To establish a murine model of chronic unified eosinophilic airway inflammation, mice were challenged with , and sinonasal mucosa and lung tissue were evaluated by immunohistochemistry, flow cytometry, and gene expression. Inhalation of conidia resulted in a Th2-biased lung and sinus inflammation that typifies allergic asthma and CRS.