Publications by authors named "Megan Kochin"
GDF15 (growth differentiation factor 15) is a stress cytokine with several proposed roles, including support of stress erythropoiesis. Higher circulating GDF15 levels are prognostic of mortality during acute respiratory distress syndrome, but the cellular sources and downstream effects of GDF15 during pathogen-mediated lung injury are unclear. We quantified GDF15 in lower respiratory tract biospecimens and plasma from patients with acute respiratory failure.
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- Klebsiella pneumoniae is a Gram-negative bacterium that can cause serious infections, and STAT1 is a key transcription factor that helps regulate T cell activity during infection.
- Researchers used a mouse model to show that a lack of STAT1 leads to increased neutrophil activity and early recruitment to the lungs, which precedes serious bacterial infection and lung damage.
- They also discovered that while IL-17 from other immune cells is crucial for combating the infection, dysfunctional CD4+ T cell responses due to STAT1 deficiency may worsen the situation, highlighting the complex role of STAT1 in managing immune responses during bacterial infections.
Non-involuting congenital hemangioma with delayed hypertrophy: A case series.
Int J Pediatr Otorhinolaryngol
June 2022
Background: Noninvoluting congenital hemangiomas (NICH) are rare and poorly understood vascular tumors that are present at birth, characterized by lack of growth after birth and lack of involution. We report uncharacteristic cases of NICH hypertrophy occurring later in life.
Methods: This is a case series describing the clinical presentation, management, and histologic characteristics of two cases of NICH hypertrophy.