Metabolomics, Lipidomics, and Antipsychotics: A Systematic Review.

Antipsychotics are an important pharmacotherapy option for the treatment of many mental illnesses. Unfortunately, selecting antipsychotics is often a trial-and-error process due to a lack of understanding as to which medications an individual patient will find most effective and best tolerated. Metabolomics, or the study of small molecules in a biosample, is an increasingly used omics platform that has the potential to identify biomarkers for medication efficacy and toxicity.

Epigenome-wide studies of antipsychotics: a systematic review and pathway meta-analysis.

Researchers have aimed to understand the mechanisms of antipsychotics through epigenetics to inform interindividual response rates. However, findings have widely varied across studies, making advancement in the field difficult. A systematic review was performed to include all epigenome-wide studies of antipsychotic treatment in humans.