Publications by authors named "Megan H Donahue"
Prognostic Factors and Epidemiology of Amyotrophic Lateral Sclerosis in Southeastern United States.
Erica Engelberg-Cook Jaimin S Shah Andre Teixeira da Silva Hucke Diana V Vera-Garcia Jany E Dagher Megan H Donahue
Mayo Clin Proc Innov Qual Outcomes
October 2024
Objective: To assess the performance of known survival predictors and evaluate their stratification capability in patients with amyotrophic lateral sclerosis (ALS).
Patients And Methods: We analyzed demographic and clinical variables collected at the Mayo Clinic, Florida ALS center during the first clinical visit of 1442 (100%) patients with ALS.
Results: Our cohort had a median (interquartile range [IQR]) age at diagnosis of 64.
Article Synopsis
- Genetic variation in the TMEM106B gene is linked to the risk and progression of frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP), with a specific genotype (rs3173615) associated with longer survival after symptoms begin.
- Research shows that the protective genotype is linked to lower accumulation of TMEM106B filaments, while the risk allele correlates with increased TMEM106B core deposition and enhanced TDP-43 dysfunction.
- The findings indicate that managing the accumulation of TMEM106B filaments may be a crucial factor in reducing disease risk and slowing down the progression of FTLD-TDP.