Publications by authors named "Megan Gottlieb"
Article Synopsis
- Bryostatin 1 activates PKC initially but leads to its depletion with long-term exposure; combining it with vincristine enhances tumor apoptosis in B-cell malignancies.
- A Phase I trial tested a 24-hour continuous infusion of bryostatin 1 followed by vincristine in refractory B-cell malignancy patients, yielding significant responses including complete and partial remissions.
- The maximum tolerated dose of bryostatin 1 was found to be 50 microg/m²/24 h, and notable antitumor activity was observed with manageable toxicities, indicating promising potential for further clinical exploration.
Background: Stat5(1) (Signal Transducer and Activator of Transcription 5) is normally phosphorylated and activated by Janus kinases. In cells transformed with BCR/ABL, Stat5 is constitutively activated by promiscuous phosphorylation. Cytometry of intracellular antigens can be used to evaluate cell treatments affecting gene expression, because it precisely provides the fraction of affected cells and the quantitative change in expression.
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