Publications by authors named "Megan Gilbert"
Public lands worldwide provide diverse resources, uses, and values, ranging from wilderness to extractive uses. Decision-making on public lands is complex as a result and is required by law to be informed by science. However, public land managers may not always have the science they need.
View Article and Find Full Text PDFArticle Synopsis
- Guidelines suggest using antibiotics for 3 to 5 days after dog bite wounds, but practices vary; this study aimed to analyze the effects of limiting antibiotics to a maximum of 3 days.
- The study reviewed dog bite injuries in patients under 18 that had primary closure, finding a significant decrease in antibiotic use from an average of 6.8 days to 4.4 days following protocol changes.
- Results indicated that shorter antibiotic duration did not raise wound infection rates, demonstrating that it's safe to minimize antibiotic use while still maintaining care quality in pediatric trauma settings.
Article Synopsis
- Mentorship in surgical training is essential for guiding trainees towards their goals, but its specific impact on burnout and well-being needs further exploration, especially as burnout rates rise among residents.
- A literature review covering studies from the US and Canada revealed 19 articles that suggest high-quality mentorship can reduce burnout and enhance well-being, though some studies reported negative effects.
- The conclusion emphasizes the need for more clarity on what constitutes effective mentorship and advocates for improving mentorship accessibility and faculty training in surgical programs.
Article Synopsis
- * In 2023, the Pediatric ITP Consortium defined refractory pediatric ITP as no platelet response after treatment with all eligible emergent therapies.
- * Patients with high disease burden or lack of platelet response, despite various treatments, are identified as a challenging group that requires further research and the potential for new treatment options.
Background: Measuring the ability of SARS-CoV-2 antibodies to neutralize live viruses remains an effective approach to quantify the level of protection of individuals. We assessed the neutralization activity against the ancestral SARS-CoV-2, Delta, Omicron BA.1, BA.
View Article and Find Full Text PDFBackground: Open hand fractures are one of the most common injuries in the pediatric population. These injuries are at higher risk of infection, especially in cases of frank contamination. Several studies on adult hand fractures are available in the literature; however, pediatric open hand fractures have yet to be extensively studied.
View Article and Find Full Text PDFBackground: Guidelines for young children with nutritional iron deficiency anemia (IDA) presenting to the emergency department (ED) are lacking, leading to variability in care. We aimed to standardize management of these patients through the development and implementation of an evidence-based algorithm using quality improvement methodology.
Procedure: Baseline data of the target population (n = 42; 60% male; median age 22.
A vaccine candidate to SARS-CoV-2 was constructed by coupling the viral receptor binding domain (RBD) to the surface of the papaya mosaic virus (PapMV) nanoparticle (nano) to generate the RBD-PapMV vaccine. Immunization of mice with the coupled RBD-PapMV vaccine enhanced the antibody titers and the T-cell mediated immune response directed to the RBD antigen as compared to immunization with the non-coupled vaccine formulation (RBD + PapMV nano). Anti-RBD antibodies, generated in vaccinated animals, neutralized SARS-CoV-2 infection in vitro against the ancestral, Delta and the Omicron variants.
View Article and Find Full Text PDFBackground: Fat Embolism Syndrome (FES) occurs when the contents (or some component of) the bone marrow is released into the circulation, generally as the result of long bone fracture. It poses significant challenges in both diagnosis and treatment and, as such, is primarily a diagnosis of exclusion with no definitive treatment. We present a case where heightened awareness of the clinical team allowed for early identification and immediate initiation of supportive care, nitric oxide (NO) for potential mitigation of right heart failure, and pharmacological treatment with atorvastatin.
View Article and Find Full Text PDFImmune thrombocytopenia (ITP) is an immune-mediated disorder resulting in platelet destruction and subsequent thrombocytopenia. Bleeding symptoms range from mild cutaneous bleeding to life-threatening hemorrhage. Romiplostim, a peptide-antibody fusion product, is a thrombopoietin receptor agonist (TPO-RA) indicated for use in patients with ITP.
View Article and Find Full Text PDFArticle Synopsis
- Field triage guidelines suggest transporting head-injured patients on blood thinners to a higher-level trauma center due to high rates of traumatic intracranial hemorrhage (tICH).
- A study involving over 1300 older adults found that the incidence of tICH was similar in patients taking anticoagulants or antiplatelets compared to those not taking them.
- The study determined that existing triage criteria were not effective in accurately identifying patients needing trauma center care, though adding anticoagulant or antiplatelet history improved sensitivity in detection.
Background: In many hospitals, children with suspected nonaccidental trauma (sNAT) are admitted to nonsurgical services (NSS). Although the surgical service (SS) initially admitted sNAT patients at our American College of Surgeons (ACS)-verified level 1 pediatric trauma center (vPTC), a change in hospital policy allowed admission to NSS. The objective of this study was to determine if the rate of care-related indicators (CRIs) varies by admission to an SS vs an NSS in the sNAT patient population.
View Article and Find Full Text PDFBackground: Since the publication of the Prophlyactic Penicillin Study II in 1995, the management of penicillin prophylaxis for children with sickle cell disease (SCD) after 5 years of age has been controversial. In this study, we sought to describe current practice patterns of pediatric hematologists related to cessation of penicillin prophylaxis for children with SCD after 5 years of age.
Procedure: We performed a cross-sectional, electronic survey of pediatric hematologists with expertise in SCD to examine practices regarding penicillin prophylaxis in children with SCD after 5 years of age.