Publications by authors named "Megan Gautier"
Article Synopsis
- * The study tested maternal choline supplementation (MCS) on a mouse model to see if it improves early endosome issues linked to these neurons.
- * Results showed MCS reduced early endosome numbers and sizes, improving their function, suggesting it could be an effective early intervention for DS and related disorders.
Article Synopsis
- Down syndrome (DS) is caused by an extra chromosome 21 and is linked to intellectual disabilities and age-related neurodegeneration, including Alzheimer's disease characteristics.
- A study using the Ts65Dn mouse model found that maternal choline supplementation (MCS) significantly protects vulnerable brain cells called basal forebrain cholinergic neurons (BFCNs) from degeneration.
- MCS also improved the health of another type of neuron, parvalbumin neurons, and showed overall neuroprotective effects, suggesting it could be a beneficial early treatment for those with DS and potentially for aging individuals as well.
Background: Phenotypic changes in vesicular compartments are an early pathological hallmark of many peripheral and central diseases. For example, accurate assessment of early endosome pathology is crucial to the study of Down syndrome (DS) and Alzheimer's disease (AD), as well as other neurological disorders with endosomal-lysosomal pathology.
New Method: We describe a method for quantification of immunolabeled early endosomes within transmitter-identified basal forebrain cholinergic neurons (BFCNs) using 3-dimensional (3D) reconstructed confocal z-stacks employing Imaris software.
There is increasing evidence that long-lasting morphologic and functional consequences can be present in the human visual system after repetitive mild traumatic brain injury (r-mTBI). The exact location and extent of the damage in this condition are not well understood. Using a recently developed mouse model of r-mTBI, we assessed the effects on the retina and optic nerve using histology and immunohistochemistry, electroretinography (ERG), and spectral-domain optical coherence tomography (SD-OCT) at 10 and 13 weeks after injury.
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