Publications by authors named "Megan C Jibilian"
Cancer Discov
October 2024
Article Synopsis
- Researchers created a new mouse model called EvoCaP to study how prostate cancer spreads to other parts of the body, including bones, liver, and lungs.
- They tracked tumor migration using a barcoding technique, finding that only a few aggressive clones are responsible for most of the cancer's spread, while the majority of cells stay localized.
- The study suggests that prostate cancer acts as a systemic disease driven by these aggressive clones, and understanding these patterns is crucial for developing new treatments.
Article Synopsis
- Metastatic prostate cancer typically shows bi-allelic mutations in key tumor suppressor genes, but often has large deletions of genes like PHLPP2 on chromosome 16q, which usually inhibits tumor growth.
- In a study using a mutant mouse model, researchers discovered that losing PHLPP2 can surprisingly hinder prostate cancer progression while supporting Myc, a critical driver of aggressive cancer.
- The researchers also found that inhibitors targeting PHLPP2 can effectively reduce Myc levels and eliminate mutant cancer cells, suggesting a potential treatment strategy by exploiting these frequent deletions as a therapeutic target.
