Publications by authors named "Megan C Fischer"
Article Synopsis
- Traumatic brain injury (TBI) can lead to issues like increased intestinal permeability, and studies show that the beta-blocker drug labetalol can help reduce this effect in rats.
- Research using a fly model of TBI found that feeding flies beta-blockers (labetalol and metoprolol) decreased intestinal permeability, but only metoprolol showed an effect when analyzing multiple fly lines, and neither drug affected mortality rates.
- The findings suggest that the relationship between disrupted intestinal barriers and TBI is similar across species, highlighting the utility of flies as a model for understanding how brain and intestinal signaling is affected after TBI in humans.
Traumatic brain injury (TBI) is a common neurological disorder whose outcomes vary widely depending on a variety of environmental factors, including diet. Using a Drosophila melanogaster TBI model that reproduces key aspects of TBI in humans, we previously found that the diet consumed immediately following a primary brain injury has a substantial effect on the incidence of mortality within 24 h (early mortality). Flies that receive equivalent primary injuries have a higher incidence of early mortality when fed high-carbohydrate diets versus water.
View Article and Find Full Text PDF