Publications by authors named "Megan B Keener"
Article Synopsis
- Patients with serrated polyposis syndrome (SPS) and their first-degree relatives (FDRs) face significantly higher colorectal cancer (CRC) risks, with a 10-fold increase for SPS patients and a 5-fold increase for their FDRs.
- The study utilized a large population database to compare cancer risks between SPS and sporadic sessile serrated lesion (SSL) patients, their relatives, and normal controls, revealing a 2.6-fold increased risk of any-site adenoma/carcinoma in FDRs of SPS patients.
- Although no elevated risks for common extracolonic cancers were found for SPS patients and their families, an increased CRC risk was noted in relatives of individuals with SSL and
Background: The outcomes, complications, and rates of secondary malignancies from radiation therapy (RT) are not known for patients with familial adenomatous polyposis (FAP).
Methods: We queried the Hereditary Gastrointestinal Cancer Registry (HGCR) for patients with FAP who received RT. Outcomes assessed included acute and late treatment toxicity and secondary malignancies.