Publications by authors named "Megan A Coghlan"
Article Synopsis
- Alzheimer's disease (AD) is a complex neurodegenerative condition leading to cognitive decline, personality changes, and behavioral issues, making it difficult to treat due to the activation of toxic brain pathways.
- Current treatments have limited effectiveness and often cause side effects, highlighting the potential of early intervention to slow disease progression.
- Curcumin, a natural compound with anti-inflammatory and antioxidant properties, shows promise for AD treatment by protecting brain cells and may work through epigenetic mechanisms, warranting further research into its therapeutic benefits.
Background: Cerebral venous thrombosis (CVT) is a rare thrombotic condition which is traditionally treated with anti-coagulation therapy. Subsets of patients with severe CVT have been treated with endovascular thrombectomy (EVT). Despite the high estimated mortality associated with severe CVT, there has been only one randomized control trial done regarding safety and efficacy of EVT in severe CVT compared to standard medical management.
View Article and Find Full Text PDFIntroduction: Increasing evidence suggests Amyotrophic Lateral Sclerosis (ALS) as a widespread pathological process comprising nonmotor features like fatigue, mild sensory symptoms, cognitive decline, and visual impairment. Measurements of retinal nerve fiber layer (RNFL) thickness using Optical Coherence Tomography (OCT) may correlate with the neurodegeneration associated with ALS. In addition to RNFL thickness, other OCT parameters have been explored in the context of diagnosing ALS and predicting disease severity.
View Article and Find Full Text PDFIntroduction Inflammation is believed to play a role in both bipolar illness and unipolar depression. Markers of inflammation are elevated during acute mood episodes. Specifically, gene expressions of the nucleotide-binding domain and leucine-rich repeat pyrin domain containing 3 ()-related proteins in peripheral blood have been purported to be upregulated in patients with bipolar disorder.
View Article and Find Full Text PDFIntroduction: Myelin oligodendrocyte glycoprotein immunoglobulin G (MOG-IgG)-associated disorders (MOGAD) is neuroimmunological disorder manifesting as episodes of ADEM, optic neuritis, transverse myelitis, brainstem encephalitis, and other CNS manifestations and notably, distinct from multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD). Current treatment strategy is high-dose intravenous methylprednisolone followed by maintenance immunotherapy for relapse prevention. The purpose of this study is to systematically create compelling evidence addressing the role of rituximab in relapse prevention among patient with MOGAD.
View Article and Find Full Text PDFArticle Synopsis
- Tetanus is a severe, rare condition that can lead to life-threatening complications, and traditional treatments like benzodiazepines come with a high risk of respiratory failure that many can't afford.
- Magnesium sulfate, a cost-effective medication available in low- and middle-income countries, was reviewed for its effectiveness in treating muscle spasms and dysautonomia in tetanus patients.
- The systematic review of 13 studies found that while magnesium sulfate didn't reduce mortality, it effectively lessened spasms and improved recovery, with minimal incidence of toxicity.