Publications by authors named "Meg Tully"
The rise of multidrug-resistant malaria requires accelerated development of novel antimalarial drugs. Pharmacokinetic-pharmacodynamic (PK-PD) models relate blood antimalarial drug concentrations with the parasite-time profile to inform dosing regimens. We performed a simulation study to assess the utility of a Bayesian hierarchical mechanistic PK-PD model for predicting parasite-time profiles for a Phase 2 study of a new antimalarial drug, cipargamin.
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- - The study explored how indoor particulate matter (PM) less than or equal to 2.5µm affects sleep-disordered breathing in children aged 6-12 in low-income neighborhoods of Boston.
- - It found that children exposed to high levels of indoor PM had 3.53 times greater odds of experiencing sleep-disordered breathing compared to those with lower exposure, even after adjusting for various factors like socioeconomic status and physical activity.
- - The results indicate that poor indoor air quality significantly contributes to sleep issues, including habitual loud snoring, among children in these communities.
This paper presents a comprehensive overview of the National Sleep Research Resource (NSRR), a National Heart Lung and Blood Institute-supported repository developed to share data from clinical studies focused on the evaluation of sleep disorders. The NSRR addresses challenges presented by the heterogeneity of sleep-related data, leveraging innovative strategies to optimize the quality and accessibility of available datasets. It provides authorized users with secure centralized access to a large quantity of sleep-related data including polysomnography, actigraphy, demographics, patient-reported outcomes, and other data.
View Article and Find Full Text PDFBackground: Plasmodium knowlesi is a zoonotic parasite that causes malaria in humans. The pathogen has a natural host reservoir in certain macaque species and is transmitted to humans via mosquitoes of the Anopheles Leucosphyrus Group. The risk of human P.
View Article and Find Full Text PDFNeighborhood disadvantage (ND) has been associated with sleep-disordered breathing (SDB) in children. However, the association between ND and SDB symptom burden and quality of life (QOL) has not yet been studied. To evaluate associations between ND with SDB symptom burden and QOL.
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- The zoonotic parasite causing malaria has different infection risks across Southeast Asia, influenced by environmental factors and mosquito transmission from macaque hosts.
- A new environmental niche modeling approach was utilized to analyze 524 occurrences of the parasite, building upon data from previous studies to improve risk predictions.
- The findings indicated that the highest risk areas are in Malaysia and Indonesia, with additional hotspots identified in the Greater Mekong Subregion, the Philippines, and Northeast India, underscoring the need for focused surveillance to aid in malaria elimination efforts.