Randomized study of teriflunomide effects on immune responses to neoantigen and recall antigens.

Objective: To evaluate immune responses to neoantigen and recall antigens in healthy subjects treated with teriflunomide.

Methods: This was a randomized, double-blind, placebo-controlled study. Subjects received oral teriflunomide (70 mg once daily for 5 days followed by 14 mg once daily for 25 days) or placebo for 30 days.

Teriflunomide versus subcutaneous interferon beta-1a in patients with relapsing multiple sclerosis: a randomised, controlled phase 3 trial.

Background: In previous studies, teriflunomide significantly reduced the annualised relapse rate (ARR) and disability progression.

Objective: This phase 3, rater-blinded study (NCT00883337) compared teriflunomide with interferon-beta-1a (IFNβ-1a).

Methods: Patients with relapsing multiple sclerosis were randomised (1:1:1) to oral teriflunomide 7-or 14 mg, or subcutaneous IFNβ-1a 44 µg.