Publications by authors named "Mefotse Saha Cyrelle Ornella"

Article Synopsis
  • Oncolytic viruses (OVs) are being explored as a treatment in immuno-oncology, but late-stage trials have faced challenges.
  • A retrospective analysis of vaccinia oncolytic virus (VOV) trials showed that lower doses may lead to better tumor responses and longer survival rates.
  • The study suggests a link between increased OV-induced neutrophils and poor outcomes, highlighting the need for better understanding of these immune cells and the importance of dose optimization in VOV clinical development.
View Article and Find Full Text PDF

Peritoneal metastasis, also known as peritoneal carcinomatosis (PC), is a refractory cancer that is typically resistant to conventional therapies. The typical treatment for PC is a combination of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Recently, research in this area has seen significant advances, particularly in immunotherapy as an alternative therapy for PC, which is very encouraging.

View Article and Find Full Text PDF

Viral replication of deleted () vaccinia virus (VV) is attenuated in resting normal cells, enabling cancer selectivity, however, replication potency of VV appears to be diminished in cancer cells. Previously, we found that wild-type herpes simplex virus (HSV () disappeared in most of the recombinant VV after multiple screenings, and only a few recombinant VV containing naturally mutated remained stable. In this study, VV of western reserve (WR) VV was replaced by A167Y mutated (), to alter nucleoside selectivity from broad spectrum to purine exclusive selectivity.

View Article and Find Full Text PDF