Publications by authors named "Meera Swami"
Article Synopsis
- External innovation in the pharmaceutical sector is key for research and development, focusing on collaboration to boost innovation and reduce costs and risks, particularly in tackling neurodegenerative diseases.
- The Eisai-University College London (UCL) partnership serves as a case study, showcasing effective industry-academic collaboration for drug discovery.
- Over the first decade, seven projects were initiated, with the first – a new anti-tau antibody for Alzheimer’s disease – progressing to clinical trials, highlighting the success of this collaborative approach.
Expansions of trinucleotide CAG/CTG repeats in somatic tissues are thought to contribute to ongoing disease progression through an affected individual's life with Huntington's disease or myotonic dystrophy. Broad ranges of repeat instability arise between individuals with expanded repeats, suggesting the existence of modifiers of repeat instability. Mice with expanded CAG/CTG repeats show variable levels of instability depending upon mouse strain.
View Article and Find Full Text PDF