Publications by authors named "Meenu Selvaraj"
Article Synopsis
- - The research presents a new type of organic transistor designed for detecting miRNA-21 concentrations in solution, using a dual gate structure to measure responses from both sensing and reference electrodes in an electrolyte.
- - This device significantly reduces the current when miRNA-21 hybridizes with oligonucleotide, achieving a detection limit as low as 35 picomolar, and displays maximum sensitivity under specific gate voltage conditions.
- - The study analyzes the hybridization reactions using a thermodynamic model, revealing that the binding energy on the device surface is about 20% lower than in solution due to surface interactions and competing reactions, while also confirming the device's selectivity using complementary techniques like SPR.
The aggregation of α-synuclein is a critical event in the pathogenesis of neurological diseases, such as Parkinson or Alzheimer. Here, we present a label-free sensor based on an Electrolyte-Gated Organic Field-Effect Transistor (EGOFET) integrated with microfluidics that allows for the detection of amounts of α-synuclein in the range from 0.25 pM to 25 nM.
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