Mechanistic Insights into the Role of MCP-1 in Diverse Liver Pathological Conditions: A Recent Update.

Monocyte chemoattractant protein-1 (MCP-1) is regarded as a crucial proinflammatory cytokine that controls the migration and entry of macrophages. It has been demonstrated that chemokine ligand 2 and its receptor, Chemokine receptor 2, are both implicated in several liver disorders. In a similar context, immunity mediators are overexpressed and stimulated by MCP-1.

Serum Levels of Heavy Metals in Patients with Prostate Cancer: A Systematic Review and Meta-analysis.

Prostate cancer (PC) is a common malignancy among men globally. Although genetic, hormonal, and environmental factors contribute to its development, the role of heavy metals remains unclear. This study evaluated serum levels of arsenic, cadmium, lead, mercury, and nickel in PC patients compared to healthy controls.

Prevalence of antihypertensive medication adherence and associated factors in India: A systematic review and meta-analysis.

Background: Non-adherence to antihypertensive medication is a key factor contributing to uncontrolled blood pressure and the subsequent complications of hypertension. Despite its importance, there is a lack of data regarding the prevalence of and factors associated with non-adherence to medication among individuals with hypertension in India. This review aimed to assess medication adherence rates among hypertensive patients in India and identify the factors influencing non-adherence.

Iron-Doped Cadmium Sulfide/Graphene Oxide (CdFeS/GO) Nanocomposites for Photocatalytic Degradation of Toxic Pollutants.

Heterogeneous photocatalysis has been widely explored as a promising solution for dye degradation due to its cost-effectiveness, ease of recovery, and use of green technology. Precisely, iron-doped cadmium sulfide (CdS) exhibits greater efficiency because of its higher charge separation, more electron transfer efficiency, and adsorption under visible region. In this study, two different ratios of iron-doped cadmium sulfide (CdFeS/GO) nanocomposites such as CdFeS/GO and CdFeS/GO were synthesized using the coprecipitation method and characterized with UV-Vis DRS, XRD, FT-IR, Raman, XPS, and HR-TEM.

Development and Psychometric Validation of Population-Based Knowledge Attitudes and Practices-Questionnaire on Fluoride (PBKAP-QF).

Fluoride exposure is a global public health concern. Understanding the knowledge, attitudes, and practices (KAP) of affected populations is essential for effective community management. This study aimed to develop and validate a KAP questionnaire to assess fluoride and its risk in general population.

Impact of fluorosis on molecular predictors in pathogenesis of type 2 diabetes associated microvascular complications.

Aim: This review presents specific insights on the molecular underpinnings of the connection between fluorosis, type 2 diabetes, and microvascular complications, along with the novel biomarkers that are available for early detection.

Summary: Fluoride is an essential trace element for the mineralization of teeth and bones in humans. Exposure to higher concentrations of fluoride has harmful effects that significantly outweigh its advantageous ones.

Prevalence of depression in hypertensive patients and its associated factors in India: A systematic review and meta-analysis.

Background: Hypertension is a prevalent health challenge in India, with a bidirectional link to depression. Recognizing the prevalence of depression among hypertensive patients and associated factors are important for better health outcomes.

Methods: A comprehensive search was conducted in PubMed, Embase, Scopus, and Google Scholar databases to identify relevant studies.

Psychological health among healthcare professionals during COVID-19 pandemic: An updated meta-analysis.

Background: The coronavirus disease 2019 (COVID-19) pandemic outbreak created a challenge to manage the health, especially the mental health of various care providers involved in treating the patients infected with the virus. Previously published literature has shown a significant effect of the pandemic on the psychological health of healthcare workers (HCWs) globally; so, this study aimed to describe the psychological health outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among Indian HCWs.

Methods: An extensive literature search was conducted in databases including PubMed and Google Scholar.

Beneficial effects of bioinspired silver nanoparticles on zebrafish embryos including a gene expression study.

Background And Purpose: Many sectors use nanoparticles and dispose of them in the aquatic environment without deciding the fate of these particles.

Experimental Approach: To identify a benign species of nanoparticles which can cause minimum harm to the aquatic environment, a comparative study was done with chemically synthesized silver nanoparticles (AgNPs) and green tea mediated synthesis (GT/AgNP) in both in vitro using human alveolar cancer cell line (A549) and normal cell line (L132), and in in vivo with zebrafish embryos.

Key Results: The in vitro studies revealed that GT/AgNPs were less toxic to normal cells than cancer cells.

Understanding the psycho-social problems of vulnerable adolescent girls and effect of intervention through life skill training.

Introduction: Children and adolescents are considered to be among the most vulnerable groups with respect to psychosocial issues who have been affected the most by this change in the family structure. The adolescent phase for girls is a critical period characterized by significant bio-psychosocial transformations. It is imperative to provide adolescents with the necessary tools and abilities to effectively confront these challenges which are provided by the members of the family.

A biomechanical reinforcement of PMMA denture base material with sericin and fibroin: A preliminary screening study.

Background: Polymethyl methacrylate (PMMA) is a commonly used denture base material, but susceptibility to fracture under functional loading remains a challenge.

Objective: This preliminary screening study aims to investigate the potential of sericin and fibroin as reinforcing agents in the PMMA denture base material.

Methods: The flexural and impact strengths of PMMA incorporated with 0.

Retrospective Cohort Study on the Surgical Outcomes of Intracapsular Thyroidectomy Vs Standard Thyroidectomy.

The focal point of thyroidectomy surgery has always been to reduce the incidence of inadvertent damage to the recurrent laryngeal nerve(RLN). The intracapsular thyroidectomy is one such technique with minimum chance of injuring the nerve. To compare retrospectively the surgical outcomes between the two methods of thyroidectomy-coventional thyroidectomy Vs intracapsular thyroidectomy.

Comparative Evaluation of Masticatory Efficiency in Various Facial Forms of Dentate and Rehabilitated Complete Denture Patients.

Purpose: To evaluate the masticatory efficiency of dentate and rehabilitated complete denture patients in various facial forms.

Materials And Methods: A total of 60 subjects were selected for the study; 30 subjects belonged to the dentate group (D Group) and 30 subjects belonged to the completely edentulous group rehabilitated with conventional complete dentures (CECD Group). All patients were divided into a subgroup (brachyfacial, mesofacial, and dolichofacial facial forms) using facial index measurement and cephalometric analysis.

Photodegradation of rhodamine-B in aqueous environment using visible-active gCN@CS-MoS nanocomposite.

Rapid industrial expansion leads to environmental pollution especially in an aqueous environment. Photocatalytic degradation is one of the most efficient and environmentally friendly techniques used to treat industrial pollution due to its complete degradation capability of a variety of water contaminants to their non-toxic state. Graphitic carbon nitride (gCN) and molybdenum disulfide (MoS) provide efficient dye degradation, but MoS has few disadvantages.

Targeting Histone 3 Variants Epigenetic Landscape and Inhibitory Immune Checkpoints: An Option for Paediatric Brain Tumours Therapy.

Despite little progress in survival rates with regular therapies, which do not provide complete care for curing pediatric brain tumors (PBTs), there is an urgent need for novel strategies to overcome the toxic effects of conventional therapies to treat PBTs. The co-inhibitory immune checkpoint molecules, , CTLA-4, PD-1/PD-L1, ., and epigenetic alterations in histone variants, , H3K27me3 that help in immune evasion at tumor microenvironment have not gained much attention in PBTs treatment.

Mechanistic view of MoS confined chitosan-polyaniline hybrid composite for the photo-oxidation of cationic dyes.

In this article, we describe the formulation of polyaniline-chitosan/MoS (PANI-CS @MoS) blended composite and evaluated its efficiency to degrade the dye molecules Rhodamine B (RhB) and Malachite Green (MG) under visible light. In the photocatalytic mechanism, the CS acts as an electron carrier and binding agent during the oxidation reaction to decrease the recombination of electrons and holes generated by the irradiation of light. FTIR, XPS, XRD, TG, Zeta Potential, UV, SEM, AFM and TEM were used to characterize the PANI-CS@MoS composite after it had been synthesized.

Biosynthesis of CoO nanomedicine by using Mollugo oppositifolia L. aqueous leaf extract and its antimicrobial, mosquito larvicidal activities.

Nanotechnology is a relatively revolutionary area that generates day-to-day advancement. It makes a significant impact on our daily life. For example, in parasitology, catalysis and cosmetics, nanoparticles possess distinctive possessions that make it possible for them in a broad range of areas.

A census of actin-associated proteins in humans.

Actin filaments help in maintaining the cell structure and coordinating cellular movements and cargo transport within the cell. Actin participates in the interaction with several proteins and also with itself to form the helical filamentous actin (F-actin). Actin-binding proteins (ABPs) and actin-associated proteins (AAPs) coordinate the actin filament assembly and processing, regulate the flux between globular G-actin and F-actin in the cell, and help maintain the cellular structure and integrity.

The role of probiotics as wound healers: an overall view.

A wound is an injury to the skin or damage to the body tissue. The healing process differs between various kinds of wounds. Treatment of hard-to-heal (chronic) wounds becomes challenging for healthcare practitioners, especially if patients have underlying health complications such as diabetes.

The age of doom scrolling - Social media's attractive addiction.

Background: Human survival requires the ability to communicate. Today's students' use of social media has opened up a slew of new possibilities; nevertheless, it is hard to say how many more may emerge in the future. As the years have gone by, the use of social networking sites has grown in popularity among teenagers.

Bridging the Gap with Nanoparticles: A Novel Approach.

Two-piece implants unavoidably present a microgap between the implant and the abutment interface. Although numerous modalities have been attempted to overcome this situation, the implant abutment interface still remains a critical point for microbial colonization, which starts an inflammatory cascade of events eventually compromising the implants. Throughout our life, cells in all biological systems are unprotected to oxidative stress leading to the formation of Reactive oxygen species which is of concern when it comes to placing implants in patients who are periodontally compromised.

Effect of dates on blood glucose and other metabolic variables: A narrative review.

Background: There is a common belief that individuals with type 2 diabetes mellitus (T2DM) must avoid consumption of dates. This article aims to review and discuss the available studies on dates on different variables, specifically blood glucose.

Methods: A survey of studies related to the influence of consumption of dates on blood glucose, glycosylated hemoglobin, lipid profile, and body weight was conducted between January 2009 and Nov 2022, using various data bases (PubMed, Medline, Google Scholar and Scopus).

Rise of Bacterial Small Proteins and Peptides in Therapeutic Applications.

Background: Polypeptides that comprise less than 100 amino acids (50 amino acids in some cases) are referred to as small proteins (SPs), however, as of date, there is no strict definition. In contrast to the small polypeptides that arise due to proteolytic activity or abrupt protein synthesis, SPs are coded by small open reading frames (sORFs) and are conventionally synthesized by ribosomes.

Purpose Of The Review: Although proteins that contain more than 100 amino acids have been studied exquisitely, studies on small proteins have been largely ignored, basically due to the unsuccessful detection of these SPs by traditional methodologies/techniques.

Comparative evaluation of the antibacterial activity of red diode laser therapy and 0.2% chlorhexidine against on implant healing abutments: An study.

Aims: The intraoral microbiota has a high potential to undergo dysbiosis, causing inflammatory changes with respect to the tissues surrounding either a natural tooth or an implant. Thus, the longevity of implant prosthesis depends on a thorough implant decontamination protocol. Among all the techniques available for doing so, laser is garnering increasing popularity, owing to minimal bleeding, high efficiency, and faster healing.

Brushite nanoparticles based electrochemical sensor for detection of uric acid, xanthine, hypoxanthine and caffeine.

The research in the field of biosensors has recently been focused on the design and development of functional electrode materials that can respond to changes in their biochemical environment. Here, we report the synthesis of dicalcium phosphate dihydrate (DCPD), also known as brushite (CaHPO·2HO) by soft chemical method and its application for electrochemical sensing of four different analytes. Phase purity, structure, chemical composition and surface morphology of the synthesized nanoparticles have been investigated using powder XRD, FTIR, SEM, XPS and HRTEM methods.