Spontaneous intracranial hypotension.

Spontaneous intracranial hypotension (SIH) is an increasingly recognised syndrome. Postural headache with typical findings on magnetic resonance imaging (MRI) are the key to diagnosis. Orthostatic headache, low cerebrospinal fluid opening pressure, and diffuse meningeal enhancement on post-contrast T1-weighted MRI brain studies are the major features of this increasingly recognised syndrome.

Linezolid-induced serotonin syndrome.

A young drug abuser was admitted to our intensive care unit for organophosphorus poisoning. He required mechanical ventilation and was started empirically on linezolid for suspected nosocomial infection. The patient developed high-grade fever with altered sensorium and clonus.

Myasthenia gravis and pure red cell aplasia: a rare association.

This is a case of a patient who presented with generalised weakness, dysphagia and ptosis. Upon evaluating the patient, she was found to have myasthenia gravis (MG) with anaemia and hypothyroidism. Further evaluation for the cause of anaemia revealed that the patient had pure red cell aplasia (PRCA).

Antiphospholipid syndrome presenting as pulmonary thrombosis and pancreatitis in a young man.

The antiphospholipid syndrome and protein-S deficiency are known prothrombotic conditions. The confirmation of the latter in a patient with a recent antiphospholipid syndrome-associated thrombosis may be difficult as protein-S levels are low in a patient in the wake of recent thrombosis, antiphospholipid antibodies themselves may be targeted against protein-S and oral anticoagulation with warfarin may further bring down protein-S levels. We report a case of a 29-year-old man presenting with widespread unprovoked thrombosis in the form of pulmonary thromboembolism, neck vein thrombosis and pancreatitis.

Syncope in a patient being treated for hepatic and intestinal amoebiasis.

A 63-year-old man presented to our hospital with amoebic liver abscess and was treated successfully for the same. During the course of his treatment, he developed syncopal attacks and was found to have Torsades de Pointes on electrocardiogram. The patient was treated with intravenous magnesium and direct current cardioversion.

Tuberous sclerosis complex presenting as bilateral large renal angiomyolipomas.

Tuberous sclerosis is an inherited disorder that can present with seizures, mental retardation, cutaneous lesions and visceral hamartomas, but can be entirely asymptomatic. The disease occurs in 1:100 000 persons in all races with nearly equal distribution between the sexes. Tuberous sclerosis is often associated with renal angiomyolipomas (AMLs), which occur in up to 80% of these patients.

Synthesis, characterization and antimicrobial activity of 1,5-bis[2-(hydroximino)-1-methyl-3-oxo-butane-1,1-diyl]thiocarbonohydrazide and 1,5-bis[2-(hydroximino) -3-oxo-1-phenyl-butane-1,1-diyl]thiocarbonohydrazide.

1,5-Bis[2-(hydroximino)-1-methyl-3-oxo-butane-1,1-diyl]thiocarbonohydrazide [IV] and 1,5-bis[2-(hydroximino)-3-oxo-1-phenyl-butane-1,1-diyl]thiocarbonohydrazide [V] were synthesized by the reaction of thiocarbonohydrazide [I] with either 3-(hydroximino)-pentane-2,4-dione [II] or 2-(hydroximino)-1-phenyl-butane-1,3-dione [III] in a 1:2 molar proportion, respectively. Compounds [IV] and [V] were characterized by elemental analyses, IR and PMR spectroscopic studies. These newly synthesized compounds have been screened or their antimicrobial activity against S.